Christie
Middle Name
Mitchell
Ballantyne, M.D.
Middle Name
Mitchell
Picture
Positions
- Professor
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Medicine
Baylor College of Medicine
- Professor
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Molecular and Human Genetics
Baylor College of Medicine
- Professor
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Molecular Physiology and Biophysics
Baylor College of Medicine
- Director
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The Maria and Alando J. Ballantyne, M.D. Atherosclerosis Clinical Research Laboratory
Baylor College of Medicine
- Director
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Center for Cardiovascular Disease Prevention
Methodist DeBakey Heart and Vascular Center
- Co-Director
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Lipid Metabolism and Atherosclerosis Clinic
Houston Methodist Hospital
- J. S. Abercrombie Chair - Atherosclerosis and Lipoprotein Research
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Baylor College of Medicine
- Chief of Cardiology
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Medicine
Baylor College of Medicine
- Chief of Cardiovascular Research
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Medicine
Baylor College of Medicine
Addresses
- Center for Cardiovascular Disease Prevention (Clinic)
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6655 Travis ST., STE 320
Houston, TX 77030
United States
Phone: (713) 798-5800
Education
- Fellowship at Howard Hughes Medical Institute and Institute for Molecular Genetics, Baylor College of Medicine
- 01/1989 - Houston, TX United States
- Clinical Fellowship at Baylor College Of Medicine Affiliate Hospitals
- 01/1987 - Houston, TX United States
- Cardiology
- Residency at University Of Texas Southwestern Affiliate Hospitals
- 01/1985 - Dallas, TX United States
- Internal Medicine
- MD from Baylor College Of Medicine
- 01/1982 - Houston, TX United States
- BA from University Of Texas At Austin
- 01/1977 - Austin, TX United States
- Internship at University of Texas Southwestern Medical School
- Dallas, Texas United States
Certifications
- Cardiovascular Disease
- American Board of Internal Medicine
- Internal Medicine
- American Board of Internal Medicine
- American Board of Clinical Lipidology
Professional Interests
- Clinical and translational research in patients with hereditary lipid disorders for the prevention and treatment of cardiovascular disease and genetic epidemiology related to lipids and cardiovascular disease
Professional Statement
Dr. Ballantyne's clinical research is the prevention of atherosclerotic vascular disease. This interest includes pharmacological studies to assess the efficacy and benefits of lipid-lowering drug therapy including trials which utilize ultrasound and MRI to examine the effects of lipid-lowering drugs on the progression of atherosclerosis. As the director of The Maria and Alando J. Ballantyne, M.D., Atherosclerosis Clinical Research Laboratory, which serves as the core laboratory for the Atherosclerosis Risk in Communities study, Dr. Ballantyne is studying whether genetic variation in combination with novel biomarkers might be useful in identifying individuals at high risk for cardiovascular disease, the metabolic syndrome, and diabetes. Both genomics and proteomics are being used to identify novel molecules that are increased with atherosclerosis and the metabolic syndrome. In addition, his group is studying how genetic variation modifies the response to lipid therapy with the goal of developing personalized diet, lifestyle, and pharmacotherapy based upon the genetic profile and clinical phenotype.Websites
Lipid Metabolism and Atherosclerosis Clinic
Selected Publications
- Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Daly DD Jr, DePalma SM, Minissian MB, Orringer CE, Smith SC Jr "2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk." J Am Coll Cardiol. 2016 July 5; 68 (1): 92-125. Pubmed PMID: 27046161
- deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW "Treatment gaps in adults with heterozygous familial hypercholesterolemia in the United States: data from the CASCADE-FH Registry." Circ Cardiovasc Genet. 2016 June ; 9 (3): 240-249. Pubmed PMID: 27013694
- Bilen O, Pokharel Y, Ballantyne CM "Genetic testing in hyperlipidemia." Cardiol Clin. 2015 May ; 33 (2): 267-275. Pubmed PMID: 25939299
- Wu H, Ballantyne CM "Skeletal muscle inflammation and insulin resistance in obesity." J Clin Invest. 2017 January 3; 127 (1): 43-54. Pubmed PMID: 28045398
- Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM "Postprandial monocyte activation in individuals with metabolic syndrome." J Clin Endocrinol Metab. 2016 November ; 101 (11): 4195-4204. Pubmed PMID: 27575945
- Pokharel Y, Sun W, Villareal DT, Selvin E, Virani SS, Ndumele CE, Hoogeveen RC, Coresh J, Boerwinkle E, Butler KR, Solomon SD, Pankow JS, Bozkurt B, Ballantyne CM, Nambi V "Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: the ARIC study." Eur J Prev Cardiol. 2017 April ; 24 (6): 628-638. Pubmed PMID: 27941157
- Ndumele CE, Matsushita K, Sang Y, Lazo M, Agarwal SK, Nambi V, Deswal A, Blumenthal RS, Ballantyne CM, Coresh J, Selvin E "N-terminal pro-brain natriuretic peptide and heart failure risk among individuals with and without obesity: the Atherosclerosis Risk in Communities (ARIC) Study." Circulation. 2016 February 16; 133 (7): 631-638. Pubmed PMID: 26746175
- Gori M, Gupta DK, Claggett B, Selvin E, Folsom AR, Matsushita K, Bello NA, Cheng S, Shah A, Skali H, Vardeny O, Ni H, Ballantyne CM, Astor BC, Klein BE, Aguilar D, Solomon SD "Natriuretic peptide and high-sensitivity troponin for cardiovascular risk prediction in diabetes: the Atherosclerosis Risk in Communities (ARIC) Study." Diabetes Care. 2016 May ; 39 (5): 677-685. Pubmed PMID: 26740635
- Nicholls SJ, Puri R, Anderson T, Ballantyne CM, Cho L, Kastelein JJ, Koenig W, Somaratne R, Kassahun H, Yang J, Wasserman SM, Scott R, Ungi I, Podolec J, Ophuis AO, Cornel JH, Borgman M, Brennan DM, Nissen SE "Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial." JAMA. 2016 December 13; 316 (22): 2373-2384. Pubmed PMID: 27846344
- Nissen SE, Stroes E, Dent-Acosta RE, Rosenson RS, Lehman SJ, Sattar N, Preiss D, Bruckert E, Ceška R, Lepor N, Ballantyne CM, Gouni-Berthold I, Elliott M, Brennan DM, Wasserman SM, Somaratne R, Scott R, Stein EA; GAUSS-3 Investigators "Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial." JAMA. 2016 April 19; 315 (15): 1580-1590. Pubmed PMID: 27039291
- Ballantyne CM, Shah S, Kher U, Hunter JA, Gill GG, Cressman MD, Ashraf TB, Johnson-Levonas AO, Mitchel YB "Lipid-modifying efficacy and tolerability of anacetrapib added to ongoing statin therapy in patients with hypercholesterolemia or low high-density lipoprotein cholesterol." Am J Cardiol. 2017 February 1; 119 (3): 388-396. Pubmed PMID: 27956003
- Ballantyne CM, Neutel J, Cropp A, Duggan W, Wang EQ, Plowchalk D, Sweeney K, Kaila N, Vincent J, Bays H "Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia." Am J Cardiol. 2015 May 1; 115 (9): 1212-1221. Pubmed PMID: 25784512
- Sabatine MS, Giugliano RP, Wiviott SD, Raal FJ, Blom DJ, Robinson J, Ballantyne CM, Somaratne R, Legg J, Wasserman SM, Scott R, Koren MJ, Stein EA; Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators "Efficacy and safety of evolocumab in reducing lipids and cardiovascular events." N Engl J Med. 2015 April 16; 372 (16): 1500-1509. Pubmed PMID: 25773607
- Miedema MD, Lopez FL, Blaha MJ, Virani SS, Coresh J, Ballantyne CM, Folsom AR "Eligibility for statin therapy according to new cholesterol guidelines and prevalent use of medication to lower lipid levels in an older US Cohort: the Atherosclerosis Risk in Communities Study Cohort." JAMA Intern Med. 2015 January ; 175 (1): 138-140. Pubmed PMID: 25401375
- Miedema MD, Lopez FL, Blaha MJ, Virani SS, Coresh J, Ballantyne CM, Folsom AR "Implications of the Eighth Joint National Committee Guidelines for the management of high blood pressure for aging adults: Atherosclerosis Risk in Communities Study." Hypertension. 2015 September ; 66 (3): 474-480. Pubmed PMID: 26150438
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