Dean Edwards
Picture

Dean Edwards
Professor
Positions
- Professor
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Mol and Cell Biology and Pathology and Immunology
Baylor College of Medicine
Houston, TX US
- Executive Director, Advanced Technology Cores
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Baylor College of Medicine
Houston, Texas
- Associate Director for Research Infrastructure
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas
- Director, Antibody-Based Proteomics Shared Resource
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas
Addresses
- Alkek Building for Biomedical Research (Office)
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Room: ABBR-R505
Houston, TX 77030
United States
(713) 798-2326
deane@bcm.edu
Education
- Post-Doctoral Fellowship at University Of Texas Health Science Center
- 01/1980 - San Antonio, Texas United States
- PhD from Medical College Of Georgia Hospital And Clinics
- 01/1976 - Augusta, Georgia United States
- BS from Ohio University
- Athens, Ohio
Honors & Awards
- Editorial Review Boards
- Molecular Endocrinology, J. Steroid Biochemistry and Molecular Biology, Breast Cancer Research and Treatment, Steroids
- Member NIH Study Section on Molecular and Cellular Endocrinology
Websites
Selected Publications
- Goswami D, Callaway C, Pascal B, Kumar R, Edwards DP, Griffin PR. "The influence of domain interactions on conformational mobility of the progesterone receptor as detected by hydrogen/deuterium exchange mass spectrometry.." Structure. 2014 22 (7): 961-973. Pubmed PMID: 24909783
- Simons SS, Edwards DP, Kumar R. "Mini Review: Dynamic structures of nuclear hormone receptors: New promises and challenges.." Molec. Endocrinol.. 2014 28 (2): 173-182. Pubmed PMID: 24284822
- Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. "Progesterone receptor and Stat5 signaling crosstalk through RANKL in mammary epithelial cells.." Molec. Endocrinol.. 2013 27 (11): 1808-1824. Pubmed PMID: 24014651
- Kumar R, Moure CM, Khan SH, Callaway C, Grimm S, Goswami D. Griffin PR, Edwards DP. "Regulation of the structurally dynamic amino-terminal domain of progesterone receptor by protein induced folding.." J. Biolog. Chem.. 2013 288 (42): 30285-30299. Pubmed PMID: 23995840
- Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai M-J, Qin J, O'Malley BW. "Proteomic analysis of coregulators bound to ER-alpha on DNA and nucleosomes reveals coregulator dynamics.." Molecular Cell. 2013 51 (2): 185-199. Pubmed PMID: 23850489
- Nickisch K, Nair HB, Kesavaram N, Das B, Garfield R, Shi SQ, Bhaskaran SS, Grimm SL, Edwards DP. "Synthesis and antiprogestational properties of novel 17-fluorinated steroids.." Steroids. 2013 78 (9): 909-919. Pubmed PMID: 23607964
- McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH "Differential Phosphorylation of Perilipin 1A at the Initiation of Lipolysis Revealed by Novel Monoclonal Antibodies and High Content Analysis.." PLoS ONE. 2013 8 (2): e55511. Pubmed PMID: 23405163
- Obr AE, Edwards DP "The biology of progesterone receptor in the normal mammary gland and in breast cancer.." Mol. Cell. Endocrinol.. 2012 June 24; 357 (41276): 41381. Pubmed PMID: 22193050
- Garza AS, Khan SH, Moure CM, Edwards DP, Kumar R "Binding-Folding Induced Regulation of AF1 Transactivation Domain of the Glucocorticoid Receptor by a Cofactor That Binds to Its DNA Binding Domain.." PLoS ONE. 2011 6 (10): e25875. Pubmed PMID: 22003412
- Buser AC, Obr AE, Kabotyanski EB, Grimm SL, Rosen JM, Edwards DP "Progesterone Receptor Directly Inhibits {beta}-Casein Gene Transcription in Mammary Epithelial Cells Through Promoting Promoter and Enhancer Repressive Chromatin Modifications.." Mol. Endocrinol.. 2011 June ; 25 (6): 955-68. Pubmed PMID: 21527503
- Wardell SE, Narayanan R, Weigel NL, Edwards DP "Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine400.." Mol. Endocrinol.. 2010 February ; 24 (2): 335-45. Pubmed PMID: 20008003
- Hill KK, Roemer SC, Jones DN, Churchill ME, Edwards DP "A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.." J. Biol. Chem.. 2009 September 4; 284 (36): 24415-24. Pubmed PMID: 19553667
- Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP "Transcriptional response of the murine mammary gland to acute progesterone exposure.." Endocrinology. 2008 December ; 149 (12): 6236-50. Pubmed PMID: 18687774
- Roemer SC, Donham DC, Sherman L, Pon VH, Edwards DP, Churchill ME "Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.." Mol. Endocrinol.. 2006 December ; 20 (12): 3042-52. Pubmed PMID: 16931575
- Wardell SE, Kwok SC, Sherman L, Hodges RS, Edwards DP "Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.." Mol. Cell. Biol.. 2005 October ; 25 (20): 8792-808. Pubmed PMID: 16199860
- Boonyaratanakornkit V, Scott MP, Ribon V, Sherman L, Anderson SM, Maller JL, Miller WT, Edwards DP "Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.." Mol. Cell. 2001 August ; 8 (2): 269-80. Pubmed PMID: 11545730
Projects
- Research Laboratory
- Baylor College of Medicine
- Dr. Edwards’ research laboratory has been funded by NIH grants for over 28 years in the areas of the biology and mechanism of action of steroid hormone receptors in normal mammary gland development and in breast cancer. Current studies include the role of progesterone as a risk factor in breast cancer through alterations of progesterone receptor (PR) signaling in early stages of breast tumorigenesis. Model systems have been developed to examine PR regulated transcriptional signaling pathways in normal mammary epithelial cells and how these pathways are dysregulated in pre-neoplastic lesions, including hyperplasias and ductal carcinoma in situ, and contribute to progression to invasive cancers. Also of interest are structure function studies of PR that have uncovered unique structural features of how coactivators interact to induce an active folded conformation of the intrinsically disordered amino terminal AF1 transcriptional activation domain. This structural information is being used for development of small molecules that interfere with PR AF1-coactivator interactions as a potential novel therapeutic target in breast cancer. Dr. Edwards also has extensive experience in Cancer Center leadership roles. Prior to joining BCM faculty in 2005, he was Director of a combined Cell Culture/ Monoclonal Antibody Shared Resource and was Program Leader of the Hormone Related Malignancies Program of the University of Colorado NCI-designated Cancer Center. Since the inception of the NCI-designated Dan L Duncan Cancer Center at BCM in 2006, Dr. Edwards has directed the Proteomics Shared Resource, has served as Associate Director for Research Infrastructure and is a member of the Cancer Center Executive Committee. As an Associate Director his role is to provide scientific guidance and oversight for all Cancer Center Shared Resources. In 2010, Dr. Edwards took on a new position as Executive Director of Institutional Advanced Technology Cores (ATC). This enabled a reorganization and centralization of Institutional Cores that included matching institutional support of Cancer Center Shared Resources as matrix Cores to fulfill the needs of both the Cancer Center and the Institution and minimize duplication of Cores. Dr. Edwards is also PI of a CPRIT (Cancer Prevention and Research Institute) supported Cancer Proteomics and Metabolomics Core Facility which provided funds for major expansion of the Cancer Center Proteomics Shared Resource and for start-up of the new Metabolomics Shared Resource.
Memberships
- Endocrine Society
- American Association for the Advancement of Science
- Association of Biomolecular Resource Facilities
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