Email

chodges@bcm.edu

Positions

Assistant Professor

Department of Molecular and Cellular Biology
Center for Precision Environmental Health
Baylor College of Medicine

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Assistant Professor (adjunct)

Department of Bioengineering
Rice University

Member

Center for Cancer Epigenetics
MD Anderson Cancer Center

Faculty Member

Graduate Program in Genetics and Genomics

Faculty Member

Graduate Program in Cancer and Cell Biology

Faculty Member

Quantitative and Computational Biosciences Graduate Program

Addresses

One Baylor Plaza, BCM 229 (Office)

Alkek Building N1317
Houston, TX 77030
United States
chodges@bcm.edu

One Baylor Plaza, BCM 229 (Lab)

Alkek Building N1302
Houston, TX 77030
United States
http://www.hodgeslab.org/

Education

Postdoctoral Fellowship at Stanford University School of Medicine

Stanford, California United States

PhD from U.C. Berkeley

Berkeley, California United States

Honors & Awards

V Scholar Award

The V Foundation

Medical Research Award

Gabrielle's Angel Foundation for Cancer Research

CPRIT Faculty Scholar

Cancer Prevention & Research Institute of Texas

Professional Interests

• Epigenomics
• Super-resolution imaging
• Chromatin and epigenetics
• Cancer biology

Professional Statement

Research in the Hodges lab focuses on mechanisms of transcription and epigenetic function in human disease. We use interdisciplinary approaches, including epigenomics, live-cell super-resolution imaging, genome editing, and structural biology, to understand chromatin regulatory systems in various settings. Our research is especially focused on new technologies, for example, improving cell-culture tumor models, as well as single-cell and single-molecule methods.

Websites

Selected Publications

• Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges* HC, Veverka* V "A ubiquitous disordered protein interaction module orchestrates transcription elongation." Science. 2021 November 26; 374 (6571): 1113-1121. Pubmed PMID: 34822292
• Hodges* HC, Stanton* BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR "Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers." Nat Struct Mol Biol. 2018 25 (1): 61-72. Pubmed PMID: 29323272
• Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy." Nat Genet. 2013 45 (6): 592-601. Pubmed PMID: 23644491
• Hodges* C, Bintu* L, Lubkowska L, Kashlev M, Bustamante C "Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II." Science. 2009 325 (5940): 626-628. Pubmed PMID: 19644123

Languages

Spanish