Jung Hwan Kim, Ph.D.
Jung Hwan Kim, Ph.D.
- Assistant Professor
Baylor College of Medicine
Houston, TX US
- BCM-Smith Medical Research Bldg (Office)
Houston, TX 77030
- Post-Doctoral Fellowship at The University of Texas at Austin
- 08/2013 - Austin, Texas United States
- Transient Hemodynamic Response in Cerebral Cortex during Brief Neural Stimulation
- PhD from University of Florida
- 12/2010 - Gainesville, Florida United States
- Development of Diffusion Tensor Imaging Based-Computational Models of Direct Infusion into the Central Nervous System
- Neurovascular coupling
- Hemodynamic response function
- Oxygen transport model
- Cerebrovascular physiology
- Computational Fluid Dynamic
- Traumatic brain injury
Professional StatementDr. Jung Hwan Kim’s career is marked by a multitude of pioneering contributions to both the mechanical engineering and neuroscience fields, specifically in the area of computational fluid modeling. He has conducted investigations aimed at understanding the transport phenomena in the central nervous system (CNS).
Dr. Kim’s primary research goals is to investigate neurovascular coupling in human brain from the blood oxygen level dependent (BOLD) response evoked by a brief stimulus, called the hemodynamic response function (HRF) with high-resolution fMRI. Dr. Kim developed a new model that is an excellent tool to interpret transient oxygen transport and hemodynamic mechanisms in the brain. The model shows how cerebral blood flow (CBF) and cerebral metabolic oxygen consumption (CMRO2) responses compete to produce the observed features of the HRF, which can tremendously expand our understanding of neurovascular coupling and the corresponding physiology. The ability to non-invasively characterize neural activity using fMRI will be of huge utility in research for normal human brain functions. A detailed understanding of neurovascular and neurometabolic coupling/decoupling, in turn, will enable its use as a diagnostic of brain pathologies (e.g. traumatic brain injury and Alzheimer’s disease).
Dr. Kim's early-stage research was related to convection enhanced delivery (CED), a fairly new drug delivery approach to deliver drugs to targets in the CNS. The main difficulty researchers had encountered when trying to deliver drugs to the brain is the blood brain barrier (BBB), which protects the brain from foreign substances. Penetrating the BBB had proven to be a problem for conventional drug delivery methods. Dr. Kim created a novel image-based computational model that optimizes local targeting of CED in the CNS. The transport properties and anatomical boundaries are assigned on a voxel-by-voxel basis using geometrical structure information from in vivo and excised rat spinal cord and brain after magnetic resonance (MR) diffusion tensor imaging.
- J. H. Kim, G.W. Astary, T. L. Nobrega, S. Kantorovich, P. R. Carney, T. H. Mareci "Dynamic Contrast-enhanced MRI of Gd-albumin Delivery to the Rat Hippocampus In vivo by Convection-Enhanced Delivery." J Neurosci Methods. 2012 209 (1): 62-73.
- J. H. Kim, G. W. Astary, S. Kantorovich, T. H. Mareci, P. R. Carney, M. Sarntinoranont "Voxelized Computational Model for Convection Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies." Ann Biomed Eng. 2012 40 (9): 2043-2058.
- J. H. Kim, R. Khan, J. Thompson, D. Ress "Model of the transient neurovascular response based on prompt arterial dilation." J Cereb Blood Flow Metab. 2013 33 (9): 1429-1439.
- J. H. Kim, D. Ress "Arterial impulse model for the BOLD response to brief neural activation." Neuroimage. 2016 January 1; 124 : 394-408.
- R. Savjani, S. Katyal, E. Halfen, J. H. Kim, D. Ress "Polar-angle representation of saccadic eye movements in human superior colliculus." Neuroimage. 2018 173 : 322-331.
- H. Oh, J. H. Kim, J. M. Yau "EPI distortion correction for concurrent human brain stimulation and T imaging at 3T." J Neurosci Meth. 2019 327 (108400):
- J. H. Kim, A. J. Taylor, D. JJ. Wang, X. Zou, D. Ress "Dynamics of the cerebral blood flow response to brief neural activity in human visual cortex." J Cereb Blood Flow Metab. 2019 August ; :
- A. J. Taylor, J. H. Kim, V. Singh, E. J. Halfen, J. Pfeuffer, D. Ress "More than BOLD: Dual‐spin populations create functional contrast." Magn Reson Med. 2019 :
- International Society of Cerebral Blood Flow
- Member (04/2013)
- Organization for Human Brain Mapping
- Member (01/2012)
- Society for Neuroscience
- Member (01/2011)
- Biomedical Engineering Society
- Quantitative characterization of human subcortical hemodynamic response - #K25HL131997 (01/01/2017 - 12/31/2020) Grant funding from NIH NHLBI
- Subcortical human brain regions play critical roles in functions from homeostasis to cognition. However, there has been a dearth of research on full assessments of human subcortical health. Quantitative characterization of subcortical responses has a great potential to unveil the mechanisms of various neurodegenerative disorders including Alzheimer’s, Huntington’s, and Parkinson’s Disease and cerebrovascular pathology such as traumatic brain injury (TBI). Here, we use functional magnetic resonance imaging (fMRI) to measure the blood oxygen level dependent (BOLD) response in subcortical regions. We will create simple multisensory integration tasks that produce BOLD response evoked by this brief brain activation – so called BOLD hemodynamic response function (HRF). We will also use various MRI methods such as proton-density weighted imaging (PDWI), and diffusion tensor imaging (DTI) for structural assessments. BOLD HRF combined with PDWI and DTI will enable remarkably complete assessments of subcortical neurovascular health, including quantification of nuclear volumes, white matter connectivity, and correlations among these metrics. In the proposed research study, we will obtain health control database for this novel metrics. We will develop a novel biomechanical transport model to predict underlying cerebral blood flow and oxygen metabolism corresponding to BOLD HRFs. We will also develop a simple but effective linear flow model based on an electrical circuit analogy to show mechanisms of blood flow response driven by local neural activity. This flow network model will be validated with flow measurement from arterial spin labelling perfusion MR imaging. The proposed model will address a critical gap in our knowledge of subcortical cerebrovascular physiology.
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