Makoto Fukuda, Ph.D.
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Makoto Fukuda, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX US
Addresses
- Children's Nutrition Research Center (Office)
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Room: CNRC-8035
Houston, TX 77030
United States
fukuda@bcm.edu
- Children's Nutrition Research Center (Lab)
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Room: CNRC-8035
Houston, TX 77030
United States
fukuda@bcm.edu
Education
- BS from Kyushu University
- Fukuoka, Japan
- PhD from University of Tokyo
- Tokyo, Japan
- Post-Doctoral Fellowship at Beth Israel Deaconess Medical Center
- Boston, MA United States
- Post-Doctoral Fellowship at University of Texas Southwestern Medical Center
- Dallas, TX United States
Websites
Selected Publications
- Kaneko K, Xu P, Cordonier EL, Chen SS, Ng A, Xu Y, Morozov A, Fukuda M. "Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions." Cell Reports. 2016 September 13; 16 : 3003-3015. Pubmed PMID: 27626668
- Williams KW*, Liu T*, Kong X*, Fukuda M*, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn J-W, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE and Elmquist JK. "Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis." Cell Metabolism. 2014 September ; 20 : 1-12. Pubmed PMID: 25017942
- Fukuda M, Williams KW, Gautron L, Elmquist JK "Induction of leptin resistance by activation of cAMP-Epac signaling.." Cell Metabolism. 2011 March 2; 13 (3): 331-9. Pubmed PMID: 21356522
- Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK "Monitoring FoxO1 localization in chemically identified neurons.." J. Neurosci.. 2008 December 10; 28 (50): 13640-8. Pubmed PMID: 19074037
- Fukuda M, Asano A, Nakamura T, Adachi M, Yoshida M, Yanagida M and Nishida E "CRM1 is responsible for intracellular transport mediated by the nuclear export signal." Nature. 1997 November ; 390 (6657): 308-311. Pubmed PMID: 9384386
- Jia L, Vianna C, Fukuda M, Berglund ED, Liu C, Sun K, Tao C, Liu T, Harper M, Lee CE, Lee S, Scherer PE, and Elmquist JK "Hepatocyte Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance.." Nature Communications. 2014 12 : 3878-3889. Pubmed PMID: 24815961
- Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK and Scherer PE. "Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice." Diabetologia. 2014 57 : 1209-1218. Pubmed PMID: 24623101
- Aziz R, Beymer M, Negrón AL, Newshan A, Yu G, Rosati B, McKinnon D, Fukuda M, Lin RZ, Mayer C, Boehm U, Acosta-Martínez M "Galanin-Like Peptide (GALP) Neurone-Specific Phosphoinositide 3-Kinase Signalling Regulates GALP mRNA Levels in the Hypothalamus of Males and Luteinising Hormone Levels in Both Sexes.." J. Neuroendocrinol. 2014 26 : 426-438. Pubmed PMID: 24796383
- Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X "Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons.." Cell Metabolism. 2013 18 : 86-98.
- Xu Y, Elmquist JK, Fukuda M "Central nervous control of energy and glucose balance: focus on the central melanocortin system.." Ann. N. Y. Acad. Sci.. 2011 December ; 1243 (1): 41288. Pubmed PMID: 22211889
- Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK "Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.." Cell Metab.. 2010 April 7; 11 (4): 286-97. Pubmed PMID: 20374961
- Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK "PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.." Cell Metab.. 2010 July 4; 12 (1): 88-95. Pubmed PMID: 20620998
- Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R "SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.." Cell Metab.. 2010 July 4; 12 (1): 78-87. Pubmed PMID: 20620997
- Donato J, Frazão R, Fukuda M, Vianna CR, Elias CF "Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons.." Endocrinology. 2010 November ; 151 (11): 5415-27. Pubmed PMID: 20881244
- Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK "5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.." Nat. Neurosci.. 2010 December ; 13 (12): 1457-9. Pubmed PMID: 21037584
- Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ and Elmquist JK "Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.." Endocrinology. 2009 150 : 4874-4882.
- Ookuma S, Fukuda M, Nishida E "Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans.." Curr. Biol.. 2003 March 4; 13 (5): 427-31. Pubmed PMID: 12620193
- Bamba C, Bobinnec Y, Fukuda M, Nishida E "The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.." Curr. Biol.. 2002 March 19; 12 (6): 503-7. Pubmed PMID: 11909538
Funding
- The gut hormone GIP drives neural leptin resistance - #14BGIA20460080 (07/01/2014 - 06/30/2016) Grant funding from American Heart Association
- Central Role of Gut Hormone GIP in Leptin Resistance and Obesity - #1R01DK104901-01A1 (09/23/2015 - 07/31/2020) Grant funding from NIH/NIDDK
- The Role of Leptin in Diet-Induced Obesity - #3092-51000-060-02 (04/01/2014 - 03/31/2019) Grant funding from USDA/CRIS
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