Positions
- Assistant Professor
-
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas United States
- Co-Director
-
CryoEM Core (Advanced Technology Core)
Baylor College of Medicine
houston, Texas United States
- member
-
Dan L Duncan Comprehensive Cancer Center
Addresses
- One Baylor Plaza (Office)
-
N410.07
HOUSTON, TX 77030
United States
Phone: (713) 798-3086
zhaow@bcm.edu
Education
- PhD from Peking University
- Beijing, China
- MS from Wuhan Univerisity
- Wuhan, Hubei China
- BS from Wuhan University
- Wuhan, Hubei China
Professional Interests
- Cryo-electron Microscopy and Tomography
- Structural Biology and Macromolecular Assemblies
- Membrane Proteins
- Antibiotic Resistance and Drug Efflux Pumps
- Nuclear Receptor
Websites
Selected Publications
- Zhang K, Wang Z, Fan GZ, Wang J, Gao S, Li Y, Sun L, Yin CC, Liu WJ "Two polar residues within C-terminal domain of M1 are critical for the formation of influenza A Virions." Cell Microbiol.. 2015 November ; : Pubmed PMID: 25939747
- Du D, Voss J, Wang Z, Chiu W, Luisi BF. "The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump." Biol Chem.. 2015 September ; : Pubmed PMID: 25803077
- Hu H*, Wang Z*, Wei R*, Fan G, Wang Q, Zhang K, Yin CC. "The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex.." Sci Rep.. 2015 February ; : Pubmed PMID: 25667046
- Du D, Wang Z, James NR, Voss JE, Klimont E, Ohene-Agyei T, Venter H, Chiu W, Luisi BF. "Structure of the AcrAB-TolC multidrug efflux pump.." Nature. 2014 May ; : Pubmed PMID: 24747401
- Yi P*, Wang Z*, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW "Structure of a biologically active estrogen receptor-coactivator complex on DNA." Mol Cell.. 2015 March ; : Pubmed PMID: 25728767
- Shi X, Wang Z, Yan L, Ezemaduka AN, Fan G, Wang R, Fu X, Yin C, Chang Z. "Small heat shock protein AgsA forms dynamic fibrils.." FEBS Lett.. 2011 November ; : Pubmed PMID: 22001209
- Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. "Gating machinery of InsP3R channels revealed by electron cryomicroscopy." Nature. 2015 November ; : Pubmed PMID: 26458101
- Zhang K, Wang Z, Liu X, Yin C, Basit Z, Xia B, Liu W. "Dissection of influenza A virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain.." PLoS One.. 2012 July ; : Pubmed PMID: 22655068
- Ni P, Wang Z, Ma X, Das NC, Sokol P, Chiu W, Dragnea B, Hagan M, Kao CC. "An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs." J Mol Biol.. 2012 June ; : Pubmed PMID: 22472420
- Wang Z, Hryc CF, Bammes B, Afonine PV, Jakana J, Chen DH, Liu X, Baker ML, Kao C, Ludtke SJ, Schmid MF, Adams PD, Chiu W. "An atomic model of brome mosaic virus using direct electron detection and real-space optimization.." Nat Commun.. 2014 September ; : Pubmed PMID: 25185801
- Hryc CF, Chen DH, Afonine PV, Jakana J, Wang Z, Haase-Pettingell C, Jiang W, Adams PD, King JA, Schmid MF, Chiu W "Accurate model annotation of a near-atomic resolution cryo-EM map." Proc Natl Acad Sci U S A. 2017 March ; : Pubmed PMID: 28270620
- Zhang K*, Ezemaduka AN*, Wang Z*, Hu H, Shi X, Liu C, Lu X, Fu X, Chang Z, Yin CC. "A novel mechanism for small heat shock proteins to function as molecular chaperones.." Sci Rep.. 2015 March ; : Pubmed PMID: 25744691
- Dilip Kumar, Xinzhe Yu, Sue E Crawford, Rodolfo Moreno, Joanita Jakana, Banumathi Sankaran, Ramakrishnan Anish, Soni Kaundal, Liya Hu, Mary K Estes, Zhao Wang, BV Venkataram Prasad "2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity." Science Advances. 2020 April 1; : Pubmed PMID: 32494598
- Xinzhe Yu, Ping Yi, Ross A Hamilton, Hong Shen, Muyuan Chen, Charles E Foulds, Michael A Mancini, Steven J Ludtke, Zhao Wang, Bert W O’Malley "Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes." Molecular Cell. 2020 July 14; : Pubmed PMID: 32668201
- Hanzhi Zhang, Yaping Pan, Liya Hu, M Ashley Hudson, Katrina S Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, BV Venkataram Prasad, Steve W Lockless, Wah Chiu, Ming Zhou "TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential." Nature communications. 2020 January 28; : Pubmed PMID: 31992706
- Muyuan Chen, James M Bell, Xiaodong Shi, Stella Y Sun, Zhao Wang, Steven J Ludtke "A complete data processing workflow for cryo-ET and subtomogram averaging." Nature methods. 2019 October 14; : Pubmed PMID: 31611690
- Ran Meng, Mengqiu Jiang, Zhicheng Cui, Jeng-Yih Chang, Kailu Yang, Joanita Jakana, Xinzhe Yu, Zhao Wang, Bo Hu, Junjie Zhang "Structural basis for the adsorption of a single-stranded RNA bacteriophage." Nature communications. 2019 July 16; : Pubmed PMID: 31311931
- Xiaodong Shi, Muyuan Chen, Zhili Yu, James M Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F Luisi, Steven J Ludtke, Zhao Wang "In situ structure and assembly of the multidrug efflux pump AcrAB-TolC." Nature communications. 2019 June 14; : Pubmed PMID: 31201302
- Qingqing Xie, Zhao Wang, Fengyun Ni, Xiaorui Chen, Jianpeng Ma, Nita Patel, Hanxin Lu, Ye Liu, Jing-Hui Tian, David Flyer, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Qinghua Wang "Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein." PloS one. 2019 February 7; : Pubmed PMID: 30730999
- Timothy L Dosey, Zhao Wang, Guizhen Fan, Zhixian Zhang, Irina I Serysheva, Wah Chiu, Theodore G Wensel "Structures of TRPV2 in distinct conformations provide insight into role of the pore turret." Nature structural & molecular biology. 2019 January ; : Pubmed PMID: 30598551
- Guizhen Fan, Mariah R Baker, Zhao Wang, Alexander B Seryshev, Steven J Ludtke, Matthew L Baker, Irina I Serysheva "Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating." Cell research. 2018 December ; : Pubmed PMID: 30470765
- Ping Yi, Zhao Wang, Qin Feng, Chao-Kai Chou, Grigore D Pintilie, Hong Shen, Charles E Foulds, Guizhen Fan, Irina Serysheva, Steven J Ludtke, Michael F Schmid, Mien-Chie Hung, Wah Chiu, Bert W O’Malley "Structural and functional impacts of ER coactivator sequential recruitment." Molecular cell. 2017 September 17; : Pubmed PMID: 28844863
- Zhao Wang, Guizhen Fan, Corey F Hryc, James N Blaza, Irina I Serysheva, Michael F Schmid, Wah Chiu, Ben F Luisi, Dijun Du "An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump." Elife. 2017 March 19; : Pubmed PMID: 28355133
- "In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution." 2021 September ; :
- "Steroid receptor-coregulator transcriptional complexes: new insights from CryoEM." Essays in Biochemistry. 2021 June ; :
- "The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1." Journal of Biological Chemistry. 2021 January ; :
Memberships
- Biophysical Society
- (01/2013)
- American Endocrine Society
- (01/2017)
Funding
- Sex Hormone Receptor Components and the Cell Genome - #5 R01 HD07857 Grant funding from NIH-NICHD
- O'Malley (PI), Co-Investigator
- Determining Chemical Interactions Mediating Biological Complex Formation by Cryo-EM - #Q-1967-20180324 Grant funding from Welch Foundation
- PI
- Molecular mechanism of Androgen Receptor mediated transcription - #R01GM143380 Grant funding from NIH-NIGMS
- Wang(PI)
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