Ongoing research in our group is focused around three major areas:
- Identifying the physiological effects and pharmacologic potential of thermogenic activation. Can beige fat thermogenesis be harnessed for its anti-diabetic actions, to lower serum lipids, and for weight loss?
- The mechanistic basis of beige fat thermogenesis. What is the mechanism by which compounds like GC-1 activate thermogenesis and is it distinct from that of other beiging agents, such as β-AR agonists?
- Can we discover other effectors capable of activating thermogenesis? 3) Performance enhancement in cold environments. Can beige fat thermogenesis be used to increase performance in the cold?