Mauro Costa-Mattioli Lab

News and Publications


Selected Publications


Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille JC, Nader K, Sonenberg N. "eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory." Cell. 2007 April 6;129(1):195-206. Pubmed PMID: 17418795

Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. "Translational control of synaptic plasticity and memory." Neuron. 2009 January 15;61(1):10-26. Pubmed PMID: 19146809

Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M. "Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage." Proc. Natl. Acad. Sci. U.S.A. 2011 March 1;108(9):3791-6. Pubmed PMID: 21307309

Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjevic K, Noebels JL, Costa-Mattioli M. "Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition."Cell. 2011 December 9;147(6):1384-96. Pubmed PMID:22153080

Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjevic K, Roman G, Costa-Mattioli M. "mTORC2 controls actin polymerization required for consolidation of long-term memory." Nat. Neurosci. 2013 April;16(4):441-8. Pubmed PMID: 23455608

Costa-Mattioli M, Monteggia LM. "mTOR complexes in neurodevelopmental and neuropsychiatric disorders."Nat Neurosc. 2013 November;16(11):1537-43. Pubmed PMID: 24165680

Costa-Mattioli M. "Switching memories ON and OFF."Science. 2008 November;322:874-875.

Buffington S, Huang W, Costa-Mattioli M. "Translational regulatory mechanism in synaptic plasticity and memory storage." Ann Rev Neurosci. 2014;37:17-38.

Viana Di Prisco G, Huang W, Buffington SA, Hsu C-C, Bonnen P, Placzek A, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. "Translational control of hippocampal mGluR-dependent long-term depression and object-place learning by eIF2." Nat Neuroscience. 2014;8:1073-82.

Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Ben Mamou, C., Marcinkiewicz, E., Yoshida, M., et al. "Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2." Nature. 2005(436):1166-1173.

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