July 1, 2104 - Key process required to weaken strength of synaptic connections, store memory identified
April 24, 2014 - Baylor College of Medicine celebrates $100 million in Albert and Margaret Alkek Foundation grant funding
July 12, 2013 - Five DeBakey Excellence in Research Award winners showcase breadth of Baylor College of Medicine research
March 4, 2013 - Novel storage mechanism allows command, control of memory
Feb. 11, 2011 - Pharmacogenetics reveal key memory protein complex
Selected Publications
Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille JC, Nader K, Sonenberg N. "eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory." Cell. 2007 April 6;129(1):195-206. Pubmed PMID: 17418795
Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. "Translational control of synaptic plasticity and memory." Neuron. 2009 January 15;61(1):10-26. Pubmed PMID: 19146809
Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M. "Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage." Proc. Natl. Acad. Sci. U.S.A. 2011 March 1;108(9):3791-6. Pubmed PMID: 21307309
Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjevic K, Noebels JL, Costa-Mattioli M. "Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition."Cell. 2011 December 9;147(6):1384-96. Pubmed PMID:22153080
Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjevic K, Roman G, Costa-Mattioli M. "mTORC2 controls actin polymerization required for consolidation of long-term memory." Nat. Neurosci. 2013 April;16(4):441-8. Pubmed PMID: 23455608
Costa-Mattioli M, Monteggia LM. "mTOR complexes in neurodevelopmental and neuropsychiatric disorders."Nat Neurosc. 2013 November;16(11):1537-43. Pubmed PMID: 24165680
Costa-Mattioli M. "Switching memories ON and OFF."Science. 2008 November;322:874-875.
Buffington S, Huang W, Costa-Mattioli M. "Translational regulatory mechanism in synaptic plasticity and memory storage." Ann Rev Neurosci. 2014;37:17-38.
Viana Di Prisco G, Huang W, Buffington SA, Hsu C-C, Bonnen P, Placzek A, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. "Translational control of hippocampal mGluR-dependent long-term depression and object-place learning by eIF2." Nat Neuroscience. 2014;8:1073-82.
Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Ben Mamou, C., Marcinkiewicz, E., Yoshida, M., et al. "Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2." Nature. 2005(436):1166-1173.
