Timothy Palzkill Lab

Palzkill Lab Members

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Timothy Palzkill, Ph.D. - Principal Investigator

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Dr. Timothy Palzkill received his bachelor of science in biology from Creighton University and a Ph.D. in genetics from University of Iowa. He did his post-doctoral training at Stanford University before joining Baylor College of Medicine Department of Molecular Virology and Microbiology in 1991. He has been the chair of the Department of Pharmacology and Chemical Biology since 2007.

His main research interest is understanding the molecular basis of beta-lactamase-mediated antibiotic resistance, developing Norovirus diagnostic tools and therapeutics, and studying molecular recognition in protein-protein interaction.

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Wanzhi Huang - Forever Lab Mom

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Wanzhi Huang worked at Palzkill Lab from the very beginning and helped Dr. Timothy Palzkill build the lab. She has helped all of the trainees and other scientists who have gone through the lab. After 27 years of service, she officially retired during September of 2020 but will always be a part of our lab.

She loves plants and swimming.

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Sreenivasa Ramana - Staff Scientist

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Allie Judge - Graduate Student

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Allie Judge is a fourth-year graduate student. She received her bachelor of science in chemistry from Millsaps College and joined the Department of Biochemistry at Baylor College of Medicine in 2018.

Our understanding of how interactions between amino acids contribute to protein function has massive implications for protein evolution and engineering. Her project uses an antibiotic resistance enzyme (CTX-M-14 β-lactamase) to study the effects of changing one amino acid on those around it—a phenomenon also known as epistasis. Primarily, her methods include molecular biology, next-generation sequencing (NGS), X-ray crystallography, and enzymology techniques.

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Lynn Su - Graduate Student

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Before coming to Baylor College of Medicine, Lynn Su received her undergraduate degree in Molecular and Cell Biology from UC Berkeley and her master’s degree in molecular medicine from National Taiwan University. Lynn is currently a fourth-year Ph.D. student in Department of Pharmacology & Chemical Biology.

She is interested in exploring the antigenic landscapes of Human Norovirus and SARS-CoV-2 using phage display and deep sequencing. 

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Jane Park - Graduate Student

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Jane Park received her bachelor's in chemistry and French studies at Rice University in 2017. She is now a fourth-year Ph.D. student at the Department of Pharmacology and Chemical Biology.

She is currently working on discovering inhibitors for antimicrobial resistance enzymes including KPC-2, NDM-1, and OXA-48 using a DNA-encoded library specifically designed to target the acid-binding pocket of these enzymes. She loves cats.

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Jiayi Fan - Graduate Student

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Jiayi Fan got her bachelor of science in pharmacy from Hong Kong Baptist University and got her masters in Food Safety and Technology from Illinois Institute of Technology. She joined Baylor College of Medicine in 2020 and is now a second-year graduate student in Palzkill Lab.

Jiayi works on phage display selection of peptides to reduce ampicillin resistance of Klebsiella pneumoniae Carbapenemase (KPC)-producing bacteria.

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Minyone Finley - Research Tech II

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Christina Nnabuife - Research Tech II

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Christina graduated from the University of Houston in May 2021, with a bachelor of science in biochemical and biophysical sciences. She joined the Palzkill Lab in October 2021, and her current projects include TEM Mutant protein purification, enzyme kinetics and aBLIP mutagenesis.

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Paola Rivera - Research Tech II

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Paola Rivera graduated from Texas Tech University with a bachelor's in biochemistry and a minor in Bbiology in 2021. She joined the Palzkill lab in 2022 and currently focuses on learning about the enzyme PBP2a and its role in inhibiting beta-lactam antibiotics.

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