Weiwei Dang Lab



1. Jo MC, Liu W, Dang W#, Qin L#. High-throughput analysis of yeast replicative aging using a novel microfluidic system. Proceedings of the National Academy of Sciences of the United States of America. (2015) 112:9364-9. PubMed ID: 26170317. (# indicates co-corresponding authors.)

2. Sen P*, Dang W*#, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke J, and Berger SL#. H3K36 methylation promotes longevity by enhancing transcription fidelity. Genes & Development. (2015) 29:1362-76. PubMed ID: 26159996. (* indicates equal contribution; # indicates co-corresponding authors.)

3. Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg J, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of Organometallic S6K1 Inhibitors. Journal of Medicinal Chemistry. (2015) 58: 305-14. PubMed ID: 25356520.

4. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA Histone Deubiquitinase Module Controls Yeast Replicative Lifespan via Sir2 Interaction. Cell Reports. (2014) 8: 477-86. PubMed ID: 25043177.

5. Dang W, Sutphin GL, Dorsey J, Otte GL, Cao K, Perry R, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, and Berger SL. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism. (2014) 19: 952-66. PubMed ID: 24814484.

6. McCauley BS and Dang W. Histone methylation and aging: Lessons learned from model systems. Biochim Biophys Acta - Gene Regulatory Mechanisms. (2014) 1839: 1454-62. PubMed ID: 24859460.

7. Dang W. The controversial world of sirtuins. Drug Discovery Today: Technologies. (2014) 12: e9-17. PubMed ID: 25027380.

8. Tsuchiyama S, Kwan E, Dang W, Bedalov A, and Kennedy BK. Sirtuins in Yeast: Phenotypes and Tools. Methods in Molecular Biology. (2013) 1077: 11-37. PubMed ID: 24014397.

9. Yuan H, Rossetto D*, Mellet H*, Dang W*, Srinivasan M, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Speicher D, Thibault P, Verreault A, Berger SL, Sternglanz R, McMahon SB, Côté J, and Marmorstein R. MYST Protein Acetyltransferase Activity Requires Active Site Lysine Autoacetylation. The EMBO Journal. (2012) 31: 58-70. PubMed ID: 22020126. (* indicates equal contribution.)

10. Edwards CR, Dang W, and Berger SL. Histone H4 Lysine 20 of Saccharomyces cerevisiae is monomethylated and functions in subtelomeric silencing. Biochemistry. (2011) 50: 10473-83. PubMed ID: 21985125.

11. Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, and Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. The EMBO Journal. (2010) 29: 158-70. PubMed ID: 19875981.

12. Dang W, Steffen KK, Perry R, Dorsey J, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, and Berger SL. Histone H4 lysine-16 acetylation regulates cellular lifespan. Nature. (2009) 459: 802-7. PubMed ID: 19516333.

13. Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K and Marmorstein R. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic and Medicinal Chemistry. (2009) 17: 7031-41. PubMed ID: 19734050.

14. Lin Y, Lu J, Zhang J, Walter W, Dang W, Wan J, Tao S, Qian J, Zhao Y, Boeke JD, Berger SL, and Zhu H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. (2009) 136: 1073-84. PubMed ID: 19303850.

15. Dang W and Bartholomew B. Domain architecture of the catalytic subunit in the ISW2-nucleosome complex. Molecular and Cellular Biology. (2007) 27: 8306–17. PubMed ID: 17908792.

16. Dang W, Kagalwala MN, and Bartholomew B. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Journal of Biological Chemistry. (2007) 282: 19418-25. PubMed ID: 17491017.

17. Dang W*, Kagalwala MN*, and Bartholomew B. Regulation of ISW2 by concerted action of histone H4 tail and extranucleosomal DNA. Molecular and Cellular Biology. (2006) 26: 7388-96. PubMed ID: 17015471. (* indicates equal contribution.)

18. Kagalwala MN, Glaus BJ, Dang W, Zofall M, and Bartholomew B. Topography of the ISW2-Nucleosome Complex: Insights into Nucleosome Spacing and Chromatin Remodeling. The EMBO Journal, (2004) 23: 2092-104. PubMed ID: 15131696.

19. Liu Y, Zheng J, Dang W, Ren H, Yu M, and Ru B. The Study of Direct ELISA and Competitive ELISA for Rabbit Metallothionein: Correlation of Induction with Zinc. Analusis. (2000) 28: 361-6.