William Lagor Lab



Recent publications (Reverse chronological order)

Li. A., Lee C.M., Hurley A.E., Jarrett K.E., De Giorgi M., Lu W., Balderrama K.S., Doerfler A.M., Deshmukh H., Ray A., Bao G.*, Lagor W.R.* A self-deleting AAV-CRISPR system for in vivo genome editing. Mol Ther Methods Clin Dev (2018) Dec 6; 12:111-122. PMID: 30619914. (*Co-corresponding)

Ni L. Scott Jr. L., Campbell H.M., Pan X., Alsina K.M., Reynolds J., Philippen L.E., Hulsurkar M., Lagor W.R., Li N., Wehrens X.H.T. Atrial-specific gene delivery using an adeno-associated viral vector. Circ. Res. (2018) Nov. 7. PMID: 30582449.

Pankowicz F.P., Barzi M., Kim K.H., Legras X., Martins C.S., Wooton-Kee C.R., Lagor W.R., Marini J.C., Elsea S.H., Bissig-Choisat B., Moore D.D., Bissig K.D. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. (2018) Aug 28. Pii. S0016-5085(18)34924-2. PMID: 30170115.

Pan X┼., Philippen L.┼, Lahiri S., Lee C., Park S.H., Word T.A., Li N., Jarrett K.E., Gupta R., Reynolds J.O., Lin J., Bao G., Lagor W.R.#, Wehrens X.H.T.# In vivo Ryr2 editing corrects catecholaminergic polymorphic ventricular tachycardia. Circ. Res. (2018) Sept. 28;123(8):953-963. PMID: 30355031. PMCID: PMC6206886. (┼Equal contributions, #Equal contributions, Co-Corresponding)

Jarrett K.E., Lee C., De Giorgi M., Hurley A., Gillard B.K., Doerfler A.M., Li A., Pownall H.J., Bao G., Lagor W.R. Somatic editing of Ldlr with Adeno-Associated Viral-CRISPR is an efficient tool for atherosclerosis research. Arterioscler Thromb Vasc Biol. (2018) Jul 19. Pii: ATVBAHA. 118.311221. PMID: 30026278. PMCID: PMC62022188.

Wang C. ┼, He Y. ┼, Xu P. ┼, Yang Y. Saito K., Xia Y., Yan X., Hinton A. Jr., Yan C., Ding H., Yu L., Shu G., Gupta R., Wu Q., Tong Q., Lagor W.R., Flores E.R., Xu Y. Tap63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat. Commun. (2018). Apr. 18;9(1):1544. (┼Equal contributions) PMICD: PMC5906443.

Pankowicz F.P., Jarrett K.E., Lagor W.R., Bissig K.D. CRISPR/Cas9: At the cutting edge of hepatology. Gut. (2017) Jul;66(7):1329-1340. PMCID: PMC5878048.

Lee C.S. ┼, Hanna A. ┼, Wang H., Dagnino-Acosta A., Joshi A., Knoblauch M., Xia Y., Georgiou D., Xu J., Long C., Amano H., Reynolds C., Dong K., Martin J., Lagor W.R., Rodney G., Sahin E., Sewry C., Hamilton S.L. A Chemical Chaperone Alleviates ER Stress and Improves Muscle Function in Mice with an RyR1 Mutation. Nat Commun. (2017) Mar 24;8:14659. (┼Equal contributions) PMCID: PMC5376670.

Jarrett K.E., Lee C.M., Yeh Y., Hsu R.H., Gupta R., Zhang M., Rodriguez P.J., Lee C.S., Gillard B.K., Bissig K.D., Pownall H.J., Martin J.F., Bao G., Lagor W.R. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. (2017) Mar 16;7:44624. PMCID: PMC5353616.

Kuwano T., Bi X., Cipollari E., Yasuda T., Lagor W.R., Szapary H.J., Tohyama J., Millar J.S., Billheimer J.T., Lyssenko N.N., Rader D.J. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but promote reverse cholesterol transport. J. Lipid Res. (2017), Jan. 30. PMCID: PMC5392748.

Palmer E.E. ┼, Jarrett K.E. ┼, Sachdev R.K., Al Zahrani F., Hashem M.O., Ibrahim N., Sampaio H., Kandula T., Macintosh R., Gupta R., Conlon D.M., Billheimer J.T., Rader D.J., Funato K., Walkey C.J., Lee C.S., Loo C., Brammah S., Elakis G., Zhu Y., Buckley M., Kirk E.P., Bye A., Alkuraya F.S., Roscioli T.#, Lagor W.R.#* Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum. Mol. Genet. (2016) July 15;25(14):3042-3054. (┼,# Equal Contributions, *Corresponding Author) PMCID: PMC5181598.

Gillard B.K., Rodriguez P.J., Fields D.W., Raya J.L., Lagor W.R., Rosales C., Courtney H.S., Gotto A.M. Jr., Pownall H.J. Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo. Biochim Biophys Acta (2016) Mar;1861(3):196-204. PMCID: PMC4804621.

Lagor W.R. ┼, Tong F ┼, Jarrett K.E., Lin W., Conlon D.M., Smith M., Wang M.Y., Yenilmez B.O., McCoy M.G., Fields D.W., O’Neill S.M., Gupta R., Kumaravel A.K., Redon V., Ahima R.S., Sturley S.L., Billheimer J.T., Rader D.J. Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutrition and Diabetes. (2015) Oct 19;5:e:181. (┼Equal contributions) PMCID: PMC4631934.

Georgiou D.K. ┼, Dagnino-Acosta A. ┼, Lee C.S. ┼, Griffin D.M., Wang H., Lagor W.R., Pautler R.G., Dirksen R.T., Hamilton S.L. Ca2+ Binding/Permeation via Calcium Channel, Cav1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. (2015) Sep 25;290(39):23751-65. (┼Equal contributions) PMCID: PMC4583036.

Bissig-Choisat B., Wang L., Legras X., Saha P.K., Chen L., Bell P., Pankowicz F.P., Hill M.C., Barzi M., Leyton C.K., Leung H.C., Kruse R.L., Himes R.W., Goss J.A., Wilson J.M., Chan L., Lagor W.R., Bissig K.D. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat. Commun. (2015) June 17, 6:7339. PMCID: PMC4557302.

O’Neill S.M., Hinkle C., Chen S.J., Sandhu A., Hovhannisyan R., Stephan S., Lagor W.R., Ahima R.S., Johnston J.C., Reilly M.P. Targeting adipose tissue via systemic gene therapy. Gene Ther. (2014) Jul;21(7):653-61. PMCID: PMC4342115.

Yang Y., Kuwano T., Lagor W.R., Albert C.J., Brenton S., Rader D.J., Brown R.J. Lipidomic Analyses of Female Mice Lacking Hepatic Lipase and Endothelial Lipase Indicate Selective Modulation of Plasma Lipid Species. Lipids. Jun;49(6):505-15. PMCID: PMC4724200.

Lagor W.R., Fields D.W., Bauer R.C., Crawford A., Abt M.C., Artis D., Wherry E.J., Rader D.J. Genetic Manipulation of the ApoF/Stat2 locus supports an important role for Type I Interferon signaling in atherosclerosis. Atherosclerosis. (2014) Mar;233(1):234-41. PMCID: PMC3936605.