The Yong Xu lab is interested in novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of body weight, feeding behavior, and glucose balance.
We generate unique mouse models, using Cre-loxP/Flp-frt strategy, with genes of interest manipulated in specific populations of neurons at the time of choice. We use these models, in combination of the modern chemogenetics/optogenetics, fiber photometry, electrophysiology and neurotracing approaches, to establish the physiological relevance of specific neural networks in the regulation of energy homeostasis, glucose balance and behaviors.
- Neural circuits and obesity mechanisms - USDA/CRIS 3092-51000-064-01S
- Neurobiology for the sex differences in energy balance - R01 DK117281
- Brain steroid receptor coactivators and energy homeostasis - P01 DK113954
- Hypothalamic Grb10 and body weight - R01 DK115761
- 5-HT neurons integrate neural inputs to regulate food intake - R01 DK120858
- Brain estrogen regulates energy and glucose balance - R01 DK125480