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Melanie Samuel Lab



Samuel MA, Samuel MA, Voinescu, EP, Lilley BN, deCabo R, Fortez M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. LKB1 and AMPK regulate synaptic remodeling in old age. Nature Neuroscience. 2014 Sep;17(9):1190-7.

Hussmann KL, Samuel MA, Kim KS, Diamond MS, Fredericksen BL. Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 2013 Mar;87(5):2814-22. PMCID: PMC3571364

Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One. 2012;7(10). PMCID: PMC3463559

Samuel MA, Zhang Y, Meister M, Sanes J. Age-related alterations in neurons of the mouse retina. J Neurosci. 2011 Nov 2;31(44):16033-44. PMCID: PMC3238393

Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12;6 (2). PMCID:PMC2820531

Diamond MS, Mehlhop E, Oliphant T, Samuel MA. The host immunologic response to West Nile encephalitis virus. Front Biosci. 2009;14:3024-34.

Szretter KJ, Samuel MA, Gilfillan S, Fuchs A, Colonna M, Diamond MS. The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep;83(18):9329-38. PMCID:PMC2738257

Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M Jr, Diamond MS. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008;82(17):8465-75. PMCID:PMC2519659

Daffis S, Samuel MA, Suthar MS, Gale M Jr, Diamond MS. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol. 2008;82(21):10349-58. PMCID:PMC2573187

Samuel MA, Wang H, Siddharthan V, Morrey JD, Diamond MS. Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. PNAS.2007;104(43):17140-5. PMCID:PMC2040476

Daffis S, Samuel MA, Keller B, Gale M Jr, Diamond MS. Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and independent mechanisms. PLOS Pathog. 2007;3(7): 1005-1015. PMCID:PMC1933455

Samuel MA, Morrey JD, Diamond MS. Caspase-3 Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis. J Virol. 2007;81(6): 2614-23. PMCID:PMC1866006

Rosenke K, Samuel MA, McDowell ET, Toerne MA, Fortunato EA. An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology. 2006;348(1):19-34.

Samuel MA, Diamond MS. Pathogenesis of West Nile virus infection: A balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006;80(19): 9346-60. PMCID:PCM1617273

Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AY. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15;393(Pt 2):503-11. PMCID:PMC1360700

Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006;80(11):5338-48. PMCID:PMC1472130

Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M Jr, Diamond MS. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol.2006;80(14):7009-19. PMCID:PMC1489062

Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale M Jr. Resistance to type I interferon defines replication fitness and virulence of West Nile virus. J Virol. 2006;80(19) 9424-34. PMCID:PMC1617238

Shrestha B. Samuel MA, Diamond MS. CD8+ T Cells Require Perforin to Clear West Nile Virus from Infected Neurons. J Virol. 2006;80(1):119-29. PMCID:PMC1317548

Pepin KM, Samuel MA, Wichman HA. Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component. Genetics. 2006;172(4):2047-56. PMCID:PMC1456406

Samuel MA, Diamond MS. Interferon α/β Protects Against West Nile Virus Infection by Restricting Cellular Tropism and Enhancing Neuronal Survival. J Virol. 2005;79(21):13350-61. PMCID:PMC1262587

Klein RS, Lin E, Zhang B, Luster A, Tollett J, Samuel MA, Engle M, Diamond MS. Neuronal CXCL10 Directs CD8+ T Cell Recruitment and Control of West Nile Virus Encephalitis. J Virol. 2005;79(17):11458-66. PMCID:PMC1193600

Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RW. An infectious West Nile virus that expresses a GFP reporter gene. Virology. 2005 Mar 30;334(1):28-40


Primary Investigator: Melanie Samuel, Ph.D.


View Dr. Samuel's bio for information about her background, training and research interest.