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Research

Publications

Master
Content

(View a complete list of published work in the Sang Jun Han Biography.)

Recent Publications

Cho YJ, Lee JE, Park MJ, O'Malley BW, Han SJ. Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis. The Journal of endocrinology. 2018;237(3):255-269.

Cho YJ, Lee SH, Park JW, Han M, Park MJ, Han SJ. Dysfunctional
signaling underlying endometriosis: current state of knowledge. Journal of molecular endocrinology.
2018;60(3):R97-r113.

Gilad Y, Eliaz Y, Yu Y, Han SJ, O'Malley BW, Lonard DM. Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Scientific reports. 2019;9(1):15099.

Han SJ*, Lee JE, Cho YJ, Park MJ, O'Malley BW. Genomic Function of Estrogen Receptor beta in Endometriosis. Endocrinology. 2019;160(11):2495-2516. (*: Corresponding Author)

Mohankumar K, Li X, Sung N, Cho YJ, Han SJ*, Safe S*. Bis Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis. Endocrinology. 2020;161(4). (*: Corresponding Authors)

Past Publications

Han SJ, Begum K, Foulds CL, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J, O’Malley BW. The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol. 2016 Jan;89(1):14-26.

Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 5;163(4):960-74.

Highlighted in Nature Reviews Immunology: Reproductive immunology: Evading immunosurveillance in endometriosis p729 | doi:10.1038/nri3942.

Comments in Le Quotidien Du Medecin (France) Lundi 9 novembre 2015-n09448.

Editor’s Choice Science Signaling. 17 Nov 2015:Vol. 8, Issue 403, pp. ec338 DOI: 10.1126/scisignal.aad8685.

Highlighted in Endometriosis News. Endometriosis Study Links Estrogen Receptor to Disease Onset, Progression.

Recommended by Faculty of 1000.

Highlighted in J Mol Endocrinol. 2016 Aug;57(2):F23-27

Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai M-J and O'Malley BW. 2005 Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. PNAS 102:9487-9492

Han SJ, Jeong J, DeMayo FJ, Xu J, Tsai SY, Tsai M-J and O’Malley BW. 2005 Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol 25:8150-8165.

Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai M-J and O’Malley BW. 2006 Steroid receptor coactivators SRC-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 20: 45-55. Selected as “Cover Story”

Han SJ, Jung SY, Malovannaya A, Kim T, Ranz BR, Qin J, O’Malley BW. 2006 A Scoring system for the Follow up Study of Nuclear Receptor Coactivator Complexes. Nuclear Receptor Signaling 4 :e014.

Han SJ, Tsai SY, Tsai M-J, and O'Malley BW. 2007 Distinct Temporal and Spatial Activities of RU486 on PR Function in Reproductive Organs of Ovariectomized Mice. Endocrinol 144(5): 2471-2486

Jeong JW, Lee KY, Han SJ, Aronow BJ, Lydon JP, O'Malley BW, DeMayo FJ. 2007 The p160 Steroid Receptor Coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone independent and dependent gene expression. Endocrinol 148(9):4238-50

Han SJ, DeMayo FJ and O’Malley BW. 2007 Dynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues. Ernst Schering Found Symp Proc. Vol. 2007/1:25-43

Han SJ, Lonard DM and O’Malley BW. 2009 Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends in Endocrinology and Metabolism 20(1):8-15

Han SJ, O’Malley BW, and DeMayo FJ, 2009 An Estrogen Receptor Alpha Activity Indicator Model in Mice. Genesis 00:1-10.

Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, DeMayo FJ, Xin L., 2012 Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 21(5):1117-23

Han SJ, Hawkins SM, Begum K, Jung YS, Kovanci E, Qin J, Lydon JP, DeMayo FJ and O’Malley BW, A novel isoform of Steroid Receptor Coactivator-1 is critical for endometriosis progression. 2012 Nature Medicine 18(7): 1102-11

Reviewed by Faculty of 1000.

Comment in: Dyson, M.T. & Bulun, S.E. Cutting SRC-1 down to size in endometriosis. Nat Med 18, 1016-1018 (2012).

Comment in: Maduro, M.R. Understanding the Pathogenesis Progression of Endometriosis, SAGE.

Comments in: Haas, M.J., Fragmentary progress in endometriosis. Science-Business eXchange 5, 8-10

Liu S, Han SJ and Smith CL, Cooperative Activation of Gene Expression by Agonists and Antagonists Mediated by Estrogen Receptor Heteroligand Dimer Complexes. 2013 Molecular Pharmacology. 83 (5):1066-77

Han SJ, O’Malley BW, The Dynamics of Nuclear Receptors and Nuclear Receptor Coregulators in the Pathogenesis of Endometriosis. 2014 Human Reproduction Update. 20(4):467-84

Selected as “Key Scientific Article” by Global Medical Discovery

Han SJ, Begum K, Foulds CL, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J amd O’Malley BW. (2015) The Dual ERa Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Molecular Pharmacology. 2015 Oct 20. pii: mol.115.100925.

Han SJ, Jung SY , Wu S, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai M-J, DeMayo FJ, O'Malley BW. (2015) Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 5;163(4):960-974.