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Swathi Balaji Lab

Publications

Master
Content

Book Chapters

The Role of Cytokines and Chemokines in Diabetic Wound Healing
Harrison Strang, Aditya Kaul, Umang Parikh, Leighanne Masri, Swetha Saravanan, Hui Li, Qi Mao, Swathi Balaji PhD.
Wound Healing, Tissue Repair and Regeneration in Diabetes. 1st (2020) Editiors: Amitava Das, Debasis Bagchi, and Sashwati Roy. In production at Elsevier

Chapter 10: Considerations for Immunohistochemistry.
Swathi Balaji #, Hui Li, Emily Steen, and Sundeep G. Keswani MD.
Success in Academic Surgery: Basic Science 2nd ed. (2019). Editiors Gregory Kennedy, Ankush Gosain, Melina Kibbe, and Scott A. LeMaire. London: Springer Nature, 2019. p. 105-144 Chapter 8. ISBN-13: 978-3-030-14644-3.
(# Corresponding author)

Fetal and Pediatric Skin Scarring
Balaji Swathi, Steen EH, Han N, King A, Bollyky PL, Keswani SG.
Facial Scars: Surgical Revision and Treatment. Editors. JR Regan Thomas and DB Hom. PMPH-USA Limited, (2019). p. 19-30 Chapter 3. ISBN-13: 978-1-607-95186-5. Book Chapter

Biology and Function of Fetal and Pediatric Skin
King A, Balaji S, Keswani SG:
Facial Skin: Contemporary Topics for the Surgeon, Facial Plastic Surgery Clinics of North America 21 (2013) p. 1-6 Chapter 1. ISSN 1064-7406

Peer Reviewed Manuscripts and Review Articles

2020

The Immune Response to Chronic Pseudomonas aeruginosa Wound Infection in Immunocompetent Mice.
Sweere JM, Ishak H, Sunkari V, Bach MS, Manasherob R, Yadava K, Ruppert SM, Sen CK, Balaji S, Keswani SG, Secor PR, Bollyky PL.
Adv Wound Care (New Rochelle). 2020 Feb 1;9(2):35-47. doi: 10.1089/wound.2019.1039. Epub 2019 Dec 18. PMID: 31903297

The Role of the Anti-Inflammatory Cytokine IL-10 in Tissue Fibrosis
Emily H. Steen, Xinyi Wang, Swathi Balaji, Manish Butte,  Paul L. Bollyky, Sundeep G. Keswani.
WHF-3M Fellowship Invited Review. Adv Wound Care (New Rochelle). 2020. (In Press)

2019

T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling.
Wang X, Balaji S, Steen EH, Li H, Rae MM, Blum AJ, Miao Q, Butte MJ, Bollyky PL, Keswani SG.
Adv Wound Care (New Rochelle). 2019 Nov 1;8(11):527-537. doi: 10.1089/wound.2019.0981. Epub 2019 Oct 16. PMID: 31637099

IL-10 Promotes Endothelial Progenitor Cell Driven Wound Neovascularization and Enhances Healing via STAT3.
Balaji S #, Steen E, Wang X, Vangapandu HV, Templeman N, Blum AJ, Moles CM, Narmoneva DA, Crombleholme TM, Butte MJ, Bollyky PL, Keswani SG..
BioRxiv [Preprint]. 2019. (# Corresponding author)

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.
Sweere JM, Van Belleghem JD, Ishak H, Bach MS, Popescu M, Sunkari V, Kaber G, Manasherob R, Suh GA, Cao X, de Vries CR, Lam DN, Marshall PL, Birukova M, Katznelson E, Lazzareschi DV, Balaji S, Keswani SG, Hawn TR, Secor PR, Bollyky PL.
Science. 2019 Mar 29;363(6434). pii: eaat9691. doi: 10.1126/science.aat9691. PMID: 30923196

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice.
Shamskhou EA, Kratochvil MJ, Orcholski ME, Nagy N, Kaber G, Steen E, Balaji S, Yuan K, Keswani S, Danielson B, Gao M, Medina C, Nathan A, Chakraborty A, Bollyky PL, De Jesus Perez VA.
Biomaterials. 2019 May;203:52-62. doi: 10.1016/j.biomaterials.2019.02.017. Epub 2019 Feb 22. PMID: 30852423

Congenital diaphragmatic hernia repair in patients on extracorporeal membrane oxygenation: How early can we repair?
Steen EH, Lee TC, Vogel AM, Fallon SC, Fernandes CJ, Style CC, Verla MA, Balaji S, Olutoye OO, Keswani SG.
J Pediatr Surg. 2019 Jan;54(1):50-54. doi: 10.1016/j.jpedsurg.2018.10.038. Epub 2018 Oct 5. PMID: 30482539

2018

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for BPD.
Balaji S, Dong X, Li H, Zhang Y, Steen E, Lingappan K.
Physiol Genomics. 2018 Nov 1;50(11):940-946. PubMed PMID: 30169132; PubMed Central PMCID: PMC6293119.  

2017

Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.
Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Harten IA, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL.
Am J Respir Cell Mol Biol. 2017 Jan;56(1):109-120. doi: 10.1165/rcmb.2016-0111OC.

Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling.
Balaji S, Wang X, King A, Le LD, Bhattacharya SS, Moles CM, Butte MJ, de Jesus Perez VA, Liechty KW, Wight TN, Crombleholme TM, Bollyky PL, Keswani SG.
FASEB J. 2017 Mar;31(3):868-881. doi: 10.1096/fj.201600856R. Epub 2016 Nov 30. PMID: 27903619

2016

Diabetic wound healing in a MMP9-/- mouse model.
Cho H, Balaji S, Hone NL, Moles CM, Sheikh AQ, Crombleholme TM, Keswani SG, Narmoneva DA.
Wound Repair Regen. 2016 Sep;24(5):829-840. doi: 10.1111/wrr.12453. Epub 2016 Jul 19. PMID: 27292154

2015

The role of interleukin-10 and hyaluronan in murine fetal fibroblast function in vitro: implications for recapitulating fetal regenerative wound healing
Balaji S*, King A*, Marsh E, LeSaint M, Bhattacharya SS, Han N, Dhamija Y, Ranjan R, Le LD, Bollyky PL, Crombleholme TM, Keswani SG.
PLoS One. 2015;10(5):e0124302. PubMed PMID: 25951109; PubMed Central PMCID: PMC4423847.

Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds.
Balaji S*, Han N*, Moles C, Shaaban AF, Bollyky PL, Crombleholme TM, Keswani SG.
Surgery. 2015 Sep;158(3):846-56. doi: 10.1016/j.surg.2015.06.034. PMID: 26266763
 (* equal contribution)

Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Keswani SG*, Balaji S*, Katz AB, King A, Omar K, Habli M, Klanke C, Crombleholme TM.
Hum Gene Ther. 2015 Mar;26(3):172-82. doi: 10.1089/hum.2014.065. PMID: 25738403
 (*equal contribution, Journal cover image)

Chemokine Involvement in Fetal and Adult Wound Healing.
Balaji S, Watson CL, Ranjan R, King A, Bollyky PL, Keswani SG.
Adv Wound Care (New Rochelle). 2015 Nov 1;4(11):660-672. Review. PMID: 26543680

2014 and older

The Role of Stem Cells in Wound Angiogenesis.
King A*, Balaji S*, Keswani SG, Crombleholme TM.
Adv Wound Care (New Rochelle). 2014 Oct 1;3(10):614-625. Review. PMID: 25300298
(* equal contribution)

Regenerative Wound Healing: The Role of Interleukin-10.
King A, Balaji S, Le LD, Crombleholme TM, Keswani SG.
Adv Wound Care (New Rochelle). 2014 Apr 1;3(4):315-323. Review. PMID: 24757588

Nanofiber Microenvironment Effectively Restores Angiogenic Potential of Diabetic Endothelial Cells.
Hurley JR, Cho H, Sheikh AQ, Balaji S, Keswani SG, Crombleholme TM, Narmoneva DA.
Adv Wound Care (New Rochelle). 2014 Nov 1;3(11):717-728. PMID: 25371854

Comparison of interleukin 10 homologs on dermal wound healing using a novel human skin ex vivo organ culture model.
Balaji S, Moles CM, Bhattacharya SS, LeSaint M, Dhamija Y, Le LD, King A, Kidd M, Bouso MF, Shaaban A, Crombleholme TM, Bollyky P, Keswani SG.
J Surg Res. 2014 Jul;190(1):358-66. doi: 10.1016/j.jss.2014.02.027. Epub 2014 Feb 22. PMID: 24814764

Using the Fetal Scarless Healing Phenotype as a Roadmap to Achieve PostnatalRegenerative Wound Repair.
Bhattacharya SS, Balaji S, Keswani SG: Journal of Wound technology 2014 N-23:40-41. Review

Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis.
Balaji S, LeSaint M, Bhattacharya SS, Moles C, Dhamija Y, Kidd M, Le LD, King A, Shaaban A, Crombleholme TM, Bollyky P, Keswani SG.
J Surg Res. 2014 Jul;190(1):367-77. doi: 10.1016/j.jss.2014.02.051. Epub 2014 Mar 2. PMID:24725678

Interleukin-10 regulates fetal extracellular matrix hyaluronan production.
King A*, Balaji S*, Le LD, Marsh E, Crombleholme TM, Keswani SG.
J Pediatr Surg. 2013 Jun;48(6):1211-1217. doi: 10.1016/j.jpedsurg.2013.03.014. PMID: 23845609
(* equal contribution)

Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing.
Keswani SG*, Balaji S*, Le LD, Leung A, Parvadia JK, Frischer J, Yamano S, Taichman N, Crombleholme TM.
Wound Repair Regen. 2013 Jul-Aug;21(4):554-62. doi: 10.1111/wrr.12065. Epub 2013 Jun 11. PMID: 23758212
(* equal contribution)

Interleukin-10 regulates the fetal hyaluronan-rich extracellular matrix via a STAT3-dependent mechanism.
King A, Balaji S, Marsh E, Le LD, Shaaban AF, Crombleholme TM, Keswani SG.
J Surg Res. 2013 Sep;184(1):671-7. doi: 10.1016/j.jss.2013.04.009. Epub 2013 Apr 24. PMID:23684616

Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications.
Balaji S, King A, Dhamija Y, Le LD, Shaaban AF, Crombleholme TM, Keswani SG.
J Surg Res. 2013 Sep;184(1):691-8. doi: 10.1016/j.jss.2013.03.051. Epub 2013 Apr 3. PMID: 23590866

The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing.
Balaji S, King A, Crombleholme TM, Keswani SG.
Adv Wound Care (New Rochelle). 2013 Jul;2(6):283-295. Review. PMID: 24527350

Biology and function of fetal and pediatric skin.
King A, Balaji S, Keswani SG.
Facial Plast Surg Clin North Am. 2013 Feb;21(1):1-6. doi: 10.1016/j.fsc.2012.10.001. Review. PMID: 23369584

The Role of Mesenchymal Stem Cells in the Regenerative Wound Healing Phenotype.
Balaji S, Keswani SG, Crombleholme TM.
Adv Wound Care (New Rochelle). 2012 Aug;1(4):159-165. Review. PMID: 24527298

Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis.
Keswani SG, Balaji S, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM.
PLoS One. 2012;7(8):e43633. doi: 10.1371/journal.pone.0043633. Epub 2012 Aug 24. PMID: 22937069
(*equal contribution)

Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing.
Keswani SG, Balaji S, Le L, Leung A, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM.
Wound Repair Regen. 2012 Jul-Aug;20(4):592-600. doi: 10.1111/j.1524-475X.2012.00810.x. Epub 2012 Jun 19. PMID: 22713157
(*equal contribution)

Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis.
Keswani SG*, Balaji S*, Le L, Leung A, Katz AB, Lim FY, Habli M, Jones HN, Wilson JM, Crombleholme TM.
PLoS One. 2012;7(8):e43633. PubMed PMID: 22937069
(*equal contribution)

Tissue-engineered provisional matrix as a novel approach to enhance diabetic wound healing.
Balaji S, Vaikunth SS, Lang SA, Sheikh AQ, Lim FY, Crombleholme TM, Narmoneva DA.
Wound Repair Regen. 2012 Jan-Feb;20(1):15-27. doi: 10.1111/j.1524-475X.2011.00750.x. Epub 2011 Dec 8. PMID: 22151855
(Wound Healing Society Anita Roberts Award for best original paper by Young Investigator 2012).

Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.
Cho H, Balaji S, Sheikh AQ, Hurley JR, Tian YF, Collier JH, Crombleholme TM, Narmoneva DA.
Acta Biomater. 2012 Jan;8(1):154-64. doi: 10.1016/j.actbio.2011.08.029. Epub 2011 Sep 6. PMID: 21925628

Complex temporal regulation of capillary morphogenesis by fibroblasts.
Hurley JR, Balaji S, Narmoneva DA.
Am J Physiol Cell Physiol. 2010 Aug;299(2):C444-53. doi: 10.1152/ajpcell.00572.2009. Epub 2010 May 26. PMID: 20505042

Angiogenic nanoscaffold accelerates diabetic wound healing and improves wound tissue strength in db/db mice
Balaji S, Sheikh AQ, Morris L, Lim FY, Crombleholme TM & Narmoneva DA.
Proceedings of the ASME Summer Bioengineering Conference, 2009 (part B) p.1173-1174.                                       

Fibroblasts induce mechanical changes in the extracellular environment and enhance capillary-like network formation.
Hurley JR, Balaji S, Narmoneva DA.
Proceedings of the ASME Summer Bioengineering Conference, 2008 (part B) p.641-642.    

In situ tissue engineering using angiogenic nanoscaffold enhances diabetic wound healing in db/db mouse model
Balaji S, Vaikunth SS, Parvadia JK, Crombleholme TM & Narmoneva DA.
Proceedings of the ASME Summer Bioengineering Conference, 2008 (part A) p. 223-224.                                          

Developing a sensor, actuator, and nanoskin based on carbon nanotube arrays
YeoHeung Y, Shanov VN, Balaji S, Tu Y, Yarmolenko S, Neralla S, Sankar J, Mall S, Lee Burggraf LW, Li G, Sabelkin VP & Schulz MJ.
Proc. of SPIE, The International Society for Optical Engineering, 2006 Vol. 6174 II, 3Z1-12