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Thomas Westbrook Lab

Publications

Master
Content

Wang, H., Yu, C., Gao, X., Welte, T., Muscarella, A.M., Zhao, H., Zhao, Z., Tao, J., Lee, B., Westbrook, T.F., Wong, S.T.C., Jin, X., Rosen, J.M., Osborne, C.K., Zhang, X.H.F. (2015) The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells. Cancer Cell 27(2):193-210. PMID: 25600338.

Hsu, T.Y-T., Simon, L.M., Neill, N., Marcotte, R., Sayad, A., Bland, C.S., Sun, T., Dominguez-Vidaña, R., Kurley, S.J., Tyagi, S., Karlin, K.L., Hartman, J.D., Renwick, A., Bernardi, R.J., Skinner, S.O., Jain, A., Orellana, M., Lagisetti, C., Golding, I., Jung, S.Y., Neilson, J.R., Zhang, X., Webb, T.R., Neel, B.G., Shaw, C.A., Westbrook, T.F., (2015) The spliceosome is a therapeutic vulnerability in Myc-driven cancer. Nature. 525(7569): 384-388. PMID: 26331541.

- Commentary: Stine, Z.E, Dang, C.V. (2015) Splicing and dicing MYC-mediated synthetic lethality. Cancer Cell. 28(4): 405-406.

- Commentary: Alderton, G. (2015) YC: splicing up your survival. Nature Reviews Cancer. 15(10): 574-574.

- Commentary: Poh, A. (2015) A vulnerable side to MYC-driven cancers. Cancer Discovery. Epub ahead of print.

- Commentary: Poh, A. (2015) Anczukow, O., Krainer, A.R. (2015) The spliceosome, a potential Achilles heel of MYC-driven cancers. Genome Medicine. 7(1): 107.

Mahamdallie, S.S., Hanks, S., Karlin, K.L., Zachariou, A., Perdeaux, E., Ruark, E., Shaw, C.A., Renwick, A., Ramsay, E., Yost, S., Elliott, A., Birch, J., Capra, M., Gray, J., Hale, J., Kingston, J., Levitt, G., McLean, T., Sheridan, E., Renwick, A., Seal, S., Stiller, C., Sebire, N., Westbrook, T.F., Rahman, N., (2015) Mutations in the transcriptional repressor REST predispose to Wilms tumor. Nature Genetics 47(12): 1471-1474.

Welte, T., Zheng, D., Kim, I.S., Tian, L, Gao, X., Wang, H., Li, J., Holdman, X.B., Herschkowitz, J.I., Pond, A., Pang, L., Liao, L., Huang, S., Xu, J., Li, Y., Lewis, M.T., Wang, T., Westbrook, T.F., Rosen, J.M., Zhang, X.H.F., Oncogenic mTOR signaling promotes myeloid-derived suppressor cell accumulation and links tumor-initiating capacity to immunosuppression. Nature Cell Biology (in press).

Karlin, K.L., Mondal, G., Hartman, J.K., Nair, A., Tyagi, S., Kurley, S.J., Bland, S.J., Hsu, T.Y-T., Renwick, A., Fang, J.E., Migliaccio, I., Callaway, C., Dominguez-Vidana, R., Nguyen, D.X., Osborne, C.K., Schiff, R., Gutierrez, C., Jung, S.Y., Edwards, D., Hilsenbeck, S.G., Zhang, X., Shaw, C.A., Couch, F.J., Westbrook, T.F., (2014) The oncogenic STP axis promotes human breast cancer via degradation of the REST tumor suppressor. Cell Reports. 9(4): 1318-1332.

Miao,Q., Ku,A., Nishino,Y., Howard,J.M., Rao,A.S., Shaver,T.M., Garcia,G.E., Le,D., Karlin, K.L, Westbrook, T.F., Poli, V., Nguyen, H. (2014) Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nature Communications, 5:4088-96. PMID: 24909826.

Terunuma, A., Putluri, N., Mishra, P., Mathe, E.A., Dorsey, T.H., Yi, M., Wallace, T.A., Issaq, H.J., Zhou, M., Killian, J.K., Stevenson, H.S., Karoly, E.D., Chan, K., Samanta, S., Edelman, D.C., Wulff, J., Starks, A.M., Yang, Y., Kittles, R.A., Yfantis, H.G., Lee, D.H., Ioffe, O.B., Schiff, R., Stephens, R.M., Meltzer, P.S., Veenstra, T.D., Westbrook, T.F., Sreekumar,A., and Ambs, S. (2014) MYC-driven 2-hydroxyglutarate is associated with breast cancer prognosis. Journal of Clinical Investigation, 124(1): 398-412.

Villegas, E., Kabotyanski, E.B., Montemayor, C., Herschkowitz, J.I., Shore, A.N., Creighton, C.J., Shaw, C.A., Westbrook, T.F., Rosen, J.M. (2014) Plk2 regulates mitotic spindle orientation and mammary gland development. Development, 141(7): 1562-1571.

Pavolova, N., Pallasch, C., Elia, A., Westbrook, T.F., Hemann, M., Elledge, S.J. (2013) A Role for PVRL4-driven Cell-Cell Interactions in Tumorigenesis. eLife.

Park, J., Al-Ramahi, I., Mollema, N., Kang, H., Lagalwar, S., Duvick, L., Lee, Y., Tan, Q., Lu, H-C., Jafar-Nejad, P., Richman, R., Liu, X., Boudreau, R.L., Davidson, B.L, Shaw, C.A., Orr, H.T.*, Westbrook, T.F.*, Botas, J.*, Zoghbi, H.Y.* (2013) Cross-species genetic screen reveals a role for Ras/MAPK in the neurodegenerative disorder Spinocerebellar Ataxia Type 1 (SCA1). Nature, 498(7454): 325-331.

- *co-corresponding

- Commentary: Ferrarelli, L.K. (2013) Conserved signals in neurodegeneration. Science Signaling. 6 (281): 143.

- Commentary: Gregg, C. (2013) Modifying Genetic Disease. Science Translational Medicine. 192: 143.

Cheung, W.K.C., Zhao, M., Liu, Z., Stevens, L.E. Cao, P.D., Fang, J., Westbrook, T.F., Nguyen, D.X. (2013) Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis. Cancer Cell, 23(6): 725-738. PMID: 23707782.

- Commentary: Watanabe, H. and Meyerson, M. (2013) Hopping between Differentiation States in Lung Adenocarcinoma. Cancer Cell, 23 (6): 707-709.

Pei, Y., Moore, C.E., Wang, J., Tewari, A.K., Eroshkin, A., Cho, Y.J., Witt, H., Korshunov, A., Read, T., Sun, J.L., Schmitt, E.M., Miller, C.R., Buckley, A.F., McLendon, R.E., Westbrook, T.F., Northcott, P.A., Taylor, M.D., Pfister, S.M., Febbo, P.G., Wechsler-Reya, R.J. (2012) An animal model of Myc-driven medulloblastoma. Cancer Cell, 21(2):155-67. PMID: 22340590.

- Commentary: Eberhart, C.G. (2012) Three Down and One to Go: Modeling Medulloblastoma Subgroups, Cancer Cell, 21(2): 137.

Kessler, J.D., Kahle, K.T., Sun, T., Meerbrey, K.L., Schlabach, M.R., Schmitt, E.M., Skinner, S.O., Xu, Q., Li, M.Z., Hartman, Z.C., Rao, M., Yu, P., Dominguez-Vidana,R., Liang, A.C., Solimini, N.L, Bernardi, R.J., Yu, B., Hsu, T., Golding, I., Luo, J., Osborne, C.K., Creighton, C.J., Hilsenbeck, S.G., Schiff, R., Shaw, C.A., Elledge, S.J., Westbrook, T.F. A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science, 335(6066): 348-53. PMID: 22157079

- Commentary: Evan, G. (2012) Cancer: taking a back door to target Myc, Science, 335(6066):293-4.

Sun, T., Aceto, N., Meerbrey, K.L., Kessler, J.D., Zhou, C., Migliaccio, I., Nguyen, D.X., Pavlova, N.N., Botero, M., Huang, J., Bernardi, R.J., Schmitt, E.M., Hu, G., Li, M.Z., Dephoure, N., Rao, M., Gygi, S.P., Creighton, C.J., Hilsenbeck, S.G., Shaw, C.A., Muzny, D., Gibbs, R., Wheeler, D., Osborne, C.K., Schiff, R., Bentires-Alj, M., Elledge, S.J., Westbrook, T.F. (2011) Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase, Cell, 144(5):703-18. PMID: 21376233.

- Commentary: Albeck, J.G., Brugge, J.S. (2011) Uncovering a tumor suppressor for triple-negative breast cancers, Cell, 144(5): 638-40.

- Commentary: M. Landis. (2011). PTPN12 loss is oncogenic in triple-negative breast cancer, Cancer Discovery (inaugural issue), 1(1): 11.

Meerbrey, K.L., Hu, G., Kessler, J.D., Roarty, K., Li, M.Z., Fang, J.E., Herschkowitz, J.I., Burrows, A.E., Ciccia, A., Sun, T., Schmitt, E.M., Bernardi, R.J., Fu, X., Bland, C.S., Cooper, T.A., Schiff, R., Rosen, J.M., Westbrook, T.F.*, Elledge, S.J.* (2011) The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo, PNAS, 108(9): 3665-70. PMID: 21307310.

- *co-corresponding, co-equal contribution

Luo, J., Emanuele, M.J., Li, D., Schlabach, M.R., Creighton, C., Westbrook, T.F., Wong, K., Elledge, S.J. (2009) A genome-wide synthetic lethal RNAi screen identifies multiple genetic dependencies of the Ras oncogene, Cell, 137(5): 835-48. PMID: 19490893.

- Commentary: Seton-Rogers, S. (2009) Therapeutics: Dependent on KRAS, Nature Reviews Cancer, 9:457.

Mulligan, P. Westbrook, T.F., Wiedemeyer, R.M., Chin, L., Elledge, S.J, Shi, Y. (2008) CDYL Bridges REST and histone methyltransferases for gene repression and suppression of cell transformation, Molecular Cell, 32(5): 718-26. PMID: 19061646.

- Commentary: McCarthy, N. (2009) Oncogene repression: CDYL and REST – a silent team, Nature Reviews Cancer, 9: 80.

Schlabach, M.R., Luo, J., Hu, G., Solimini, N.L., Xu, Q., Li, M.Z., Zhao, Z., Smogorzewska, A., Sowa, M.E., Ang, X.L., Westbrook, T.F., Liang, A.C., Chang, K., Hackett, J.A., Harper, J.W., Hannon, G.J., Elledge, S.J. (2008) Cancer Proliferation Gene Discovery Through Functional Genomics, Science, 319(5863): 620-624.* PMID: 18239126.

- Commentary: Hayden, E.C.(2008) ‘Normal’ genes key to cancer growth. Nature, 451(7179): 615.

Westbrook, T.F., Hu, G., Ang, X.L., Mulligan, P., Liang, A., Leng, Y., Shi, Y., Harper, J.W., Elledge, S.J. (2008) SCFbTRCP Controls Oncogenic Transformation and Neural Differentiation Through REST Degradation, Nature, 452(7185):370-374. PMID: 18354483.

- Commentary: Weissman, A.M. (2008) How much REST is enough? Cancer cell, 13(5):381-383.

- Commentary: Alderton, G.K. (2008) Signalling: An oncogene becomes RESTless. Nature Reviews Cancer, 8: 327.

Westbrook, T.F., Stegmeier, F., Elledge, S.J. (2005) Dissecting Cancer Pathways and Vulnerabilities with RNAi. LXX Cold Spring Harbor Symposium on Quantitative Biology: Molecular Approaches to Controlling Cancer. 70: 434-444. PMID: 16869781.

Westbrook, T.F., Martin, E.S., Schlabach, M.R., Leng Y., Liang, A.C., Feng, B., Zhao, J.J., Roberts, T.M., Mandel, G., Hannon, G.J., DePinho, R.A., Chin, L., Elledge, S.J. (2005) A Genetic Screen for Candidate Tumor Suppressors Identifies REST. Cell, 121(6):837-848.* PMID: 15960972.

- Commentary: Downward, J. (2005) RNA interference libraries prove their worth in hunt for tumor suppressor genes. Cell, 121(6): 813-815.-

- Commentary: Bangham, J. (2005) A Screen Success. Nature Reviews Cancer, 5: 586.

Paddison, P.J., Silva, J.M., Conklin, D.S., Schlabach, M., Li, M., Aruleba, S., Balija, V., O’Shaughnessy, A., Gnoj, L., Scobie, K., Chang, K., Westbrook, T.F., Sachidanandam, R., McCombie, W.R., Elledge, S.J., Hannon, G.J. (2004) A Resource for Large-Scale RNAi Based Screens in Mammals. Nature, 428(6981) :375-378. PMID: 15042091.

- Commentary: Fraser, A. (2004) RNA interference: Human genes hit the big screen. Nature, 428(6981): 377.