About the Core
The Neuropathology Core provides the capability to perform structural studies of the brain. It provides users anatomical expertise in preparing and analyzing developing and adult brains for deviations from typical structure in species ranging from rodents through to primates, including human. It also now offers the same high quality service for studies of the fruit fly Drosophila melanogaster.
- Tissue cutting
- Basic Imaging
- Golgi-Cox staining
- Routine Histology (such as H&E, Nissl staining)
- Training for perfusion/dissection
- Training for brain dissection
- Training for intricate dissection (embryo, etc.)
- Transmission Electron Microscopy (TEM)
Recent Publications Using the Core
- Rousseaux MWC, Tschumperlin T,...Sillitoe RV, Zoghbi HY, Orr HT. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. 2018 Mar 21;97(6):1235-1243.
- White JJ, Sillitoe RV. Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice. Nat Commun. 2017 Apr 4;8:14912.
- White JJ, Arancillo M, King A, Lin T, Miterko LN, Gebre SA, Sillitoe RV. Pathogenesis of severe ataxia and tremor without the typical signs of neurodegeneration. Neurobiol Dis. 2016 Feb;86:86-98.