Patients with neonatal-onset seizures become eligible for ERGENT after a standard-of-care diagnostic work-up for more common metabolic, non-genetic, and/or structural causes of neonatal seizures has been performed and been negative. This required work-up includes blood studies, brain MRI, and EEG, and often may include lumbar puncture. Eligibility requires either (1) an electrographic (EEG proven) seizure or a clearly abnormal interictal EEG background. However, patients with histories typical of Benign Familial Neonatal Seizures (autosomal dominant inheritance pattern, normal or near normal interictal EEG and neurological exam) are eligible. The neonate’s neurological exam, when not seizing, may be normal or abnormal. Seizure onset must occur by 14 days post term birth, and application must be made online within 30 days of seizure onset.