There are now several antiviral medications licensed for the treatment of serious CMV disease. The two antiviral medications evaluated in clinical trials and recommended by CMV experts are ganciclovir and valganciclovir. Antiviral treatment should be considered for newborns with congenital CMV disease, and started in the newborn with signs and symptoms associated with congenital CMV within the first month of life, or as soon as possible after diagnosis is confirmed. Ganciclovir is administered intravenously (IV) for usually 6 weeks of treatment. Side effects of IV ganciclovir include irritation at the site of the IV (therefore usually a central line is used to administer the medication safely), and abnormalities in the blood count, especially neutropenia or low infection fighting cells. This side effect may occur in about two thirds of newborns who receive this IV treatment. Occasionally, other bone marrow suppression can occur or a mild drug induced hepatitis has been seen in some children. These side effects are managed by halting the medication temporarily, rechecking the abnormal tests, and restarting the medication when the effects have resolved. Valganciclovir (Valcyte) is administered orally by mouth for usually 6 months of treatment. Side effects of oral valganciclovir include mild upset of the gastrointestinal tract, mild disruption of sleep patterns, and abnormalities in the blood count, especially neutropenia or low infection fighting cells. This side effect may occur in about one fifth of newborns who receive this oral treatment, much less than IV ganciclovir treatment. It is important to make sure the original Valcyte clear solution is provided by the pharmacist and given to your baby. In pharmacy compounding of Valcyte tablets to make a compounded suspension is no longer recommended. Clinical research trials may also be in progress to determine if longer antiviral treatment or new antiviral treatments help babies with severe disease at birth due to CMV infection. You may contact your doctor, www.clinicaltrials.gov, or the Congenital CMV Research, Clinic and Registry program here in Houston Texas for the names of participants near you who may be knowledgeable in treatment of congenital CMV infection.