Registration
Registration is now closed.
Dec. 2, 2020 − Virtual Workshop
9 a.m. − 12 p.m. via Zoom
Target audience
Residents, fellows and faculty interested in performing systematic reviews
Objectives
- Design a protocol for a systematic review of intervention.
- Assemble a systematic review in Revman software and perform meta-analysis.
Course director
Mohan Pammi, M.D., Ph.D., MRCPCH
From the Evidence Academy at Texas Children's Hospital
Ganga Gokulakrishnan, Aarti Bavare, Krithika Lingappan, Nirica Borges, Melissa Carbajal
Course Faculty

Roger F. Soll, M.D.
Professor, University of Vermont, Coordinating Editor of Cochrane Neonatal Review Group, and President of Vermont Oxford Network

Prakesh Shah, M.D., MSc, M.B.B.S.
Professor, Pediatrician-in-Chief, University of Toronto and Editor, Cochrane Neonatal Review Group

Mohan Pammi, M.D., Ph.D., MRCPCH
Associate Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital and Associate Editor, Cochrane Neonatal Review Group

Ganga Gokulakrishnan, M.B.B.S.
Assistant Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital

Nirica Borges, M.D., FAAP, CMQ
Assistant Professor, Pediatrics-Critical Care, Baylor College of Medicine
Systematic reviews comprise the highest level in the hierarchy of evidence to inform clinical practice. Authors of systematic reviews first generate a protocol with the relevant clinical question, specify objectives, delineate the search strategy to identify all relevant publications and prespecify methodology of the review and meta-analysis, ‘a priori’. Once the protocol is registered with Cochrane or other registries, the review is performed first searching for studies that are eligible for inclusion and performing critical appraisal of included studies. A systematic review may be performed with only qualitative synthesis when meta-analysis, the statistical synthesis of data is not appropriate. Retrieving, appraising and synthesizing literature fulfills ACGME core competencies of patient care, medical knowledge and practice-based learning and promotes educational scholarship.
This workshop will enable learners to develop a roadmap for performing a systematic review using Cochrane methodology. The session will lead learners through each of the steps of creation of a protocol and systematic review. Knowledge and skills imparted will relate to formulating the clinical question in PICOT format (Population, Intervention, Comparators, Outcomes and Trial design), crystallizing the objectives of the review, developing a comprehensive search strategy, identifying studies eligible for inclusion in the review using the PRISMA flow diagram, appraising the evidence using accepted methods for evaluating risk of bias, extract data and perform analysis and meta-analysis of relevant data. Participants will learn to present results in summary findings tables, rate the quality of evidence using ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and derive conclusions for clinical practice and research. The workshop will close with a question and answer session and discussion of ideas for participants to perform systematic reviews at their home institutions.
Who Should Participate?
Faculty and trainees at any stage in their career who are interested in learning the principles and practice of evidence-based medicine.
Time |
Content |
Teaching Method |
Facilitator |
10 minutes |
Welcome, faculty introductions, |
Large group discussion |
Mohan Pammi/Nirica Borges |
15 minutes |
A roadmap for performing systematic reviews, formulating the PICOT question and stating the review objectives |
Didactic with zoom poll/annotation |
Roger Soll |
15 minutes |
Formulate the PICOT question and objectives for a systematic review |
Handouts with sample scenarios for PICOT questions |
Zoom break out session for 5groups |
20 minutes |
VIDEO: Develop search strategy for different databases |
Didactic |
Ganga Gokulakrishnan, NiricaBorges, |
10 minutes |
Q & A |
Handouts |
|
|
|
Bio break-10 minutes |
|
15 minutes |
Appraise studies and risk of bias in included studies |
Didactic/ARS |
Prakesh S Shah |
15 minutes |
Appraise studies and risk of bias in included studies |
Small group activity |
|
5 minutes |
Get back questions and discussion |
|
|
30 minutes |
Data extraction from included studies, data entry into Revman and analysis |
Didactic |
Mohan Pammi |
|
|
Bio break-10 minutes |
|
20 minutes |
GRADE approach to rate certainty of evidence |
Didactic |
Roger Soll |
10 minutes |
GRADE certainty of evidence using examples of outcomes |
Small group activity |
Zoom break out session with 5groups |
10 minutes |
Discussion |
|
|
20 minutes |
Results, discussion and conclusions
|
Large group interactive session |
Roger Soll |