Deep Brain Stimulation for OCD (H-40255)
Development of Adaptive Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder (OCD)
The purpose of this study is to look for new ways to treat obsessive compulsive disorder. OCD, which affects two to three percent of the U.S. population, is a disabling disorder marked by unwanted, intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Current treatments, including medications (SSRIs) and cognitive behavioral therapy (specifically ERP), do not work for everyone with OCD. Patients with treatment-resistant OCD may benefit from deep brain stimulation (DBS), a neurosurgical technique where small electrodes are implanted into the brain, which provide electrical stimulation to help control OCD symptoms. The goal of this research study is to gather data to classify OCD symptoms and other mood states in order to develop an adaptive DBS system, which can automatically adjust stimulation as needed based on the individual to control OCD symptoms.
Participation could be up to 18 months and involves:
- A screening visit
- A baseline visit
- An inpatient surgery and post-operation evaluation
- Post-op visits to record and program the DBS device
- Follow-up visits every 2 weeks for 2 months, then once a month up to month 18
The visits are in person and can include brain imaging (MRI scans), EEG recordings, heart rate monitoring, and video recordings.
Participants will be compensated for their time.
Study Site: Baylor College of Medicine
Study Doctor: Wayne Goodman, M.D.