Francis
Middle Name
T.F.
Tsai, D.Phil.
Middle Name
T.F.
Picture
Positions
- Professor
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Biochemistry & Molecular Biology
Baylor College of Medicine
- Professor
-
Molecular & Cellular Biology
Baylor College of Medicine
- Professor
-
Molecular Virology & Microbiology
Baylor College of Medicine
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Member
-
Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States
Addresses
- Department of Biochemistry (Office)
-
Baylor College of Medicine
Houston, TX 77030-3498
United States
Education
- Advanced Training from Yale University / HHMI
- 10/2000 - New Haven, Connecticut United States
- D.Phil. from University of Oxford
- 10/1997 - Oxford, Oxon United Kingdom
- BSc from Univ. of London (Imperial College)
- 08/1993 - London, South Kensington United Kingdom
Honors & Awards
- Georgia Cancer Center Distinguished Guest Lecturer
- 01/2019
- Norman Hackerman Award in Chemical Research
- 02/2008
- Research Scholar of the American Cancer Society
- 01/2008 - 12/2011
- Scientist of the American Heart Association
- 01/2001 - 12/2004
- Wellcome Trust International Prize Travelling Postdoctoral Fellow
- 01/1997 - 12/1999
- NIH NRSA (F32) Individual Postdoctoral Fellowship (declined)
- 11/1996
- Associate of the Royal College of Science, United Kingdom
- 08/1993
Professional Interests
- Protein Structure-Function and Protein Folding
- Structural Biology and Macromolecular Assemblies
- Cryo-electron Microscopy and Tomography
- Membranes and Membrane Proteins
- Enzymology
- Gene Expression and Regulation
- Cancer
- Nano Medicine and Drug Design
- Antibiotic Resistance
- Bacteria and Phage
- Yeast and Dictyostelium
Websites
Tsai Lab Twitter
Selected Publications
- Maneix L, Sweeney MA, Lee S, Iakova P, Moree SE, Sahin E, Lulla P, Yellapragada SV, Tsai FTF, Catic A "The mitochondrial protease LonP1 promotes proteasome inhibitor resistance in multiple myeloma." Cancers. 2021 13 : 843. Pubmed PMID: 33671345
- Rizzolo K, Yu AYH, Ologbenla A, Kim SR, Haojie Z, Ishimori K, Thibault G, Leung E, Zhang Y, Teng M, Haniszewski M, Miah N, Phanse S, Minic Z, Lee S, Caballero JD, Babu M, Tsai FTF, Saio T, Houry W "Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex." Nature Commun. 2021 12 : 281. Pubmed PMID: 33436616
- Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D "The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis." BMC Biol. 2020 18 : 10. Pubmed PMID: 31987035
- Tsai JT, Sung N, Lee J, Chang C, Lee S, Tsai FTF "Crystal structure of the YcjX stress protein reveals a Ras-like GTP-binding protein." J Mol Biol. 2019 431 : 3179-90. Pubmed PMID: 31202886
- Lee S, Roh SH, Lee J, Sung N, Liu J, Tsai FTF "Cryo-EM structures of the Hsp104 protein disaggregase captured in the ATP conformation." Cell Rep. 2019 26 : 29-36. Pubmed PMID: 30605683
- Sung N, Lee J, Kim JH, Chang C, Joachimiak A, Lee S, Tsai FT "Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate." Proc. Natl. Acad. Sci. USA. 2016 113 : 2952-7. Pubmed PMID: 26929380
- Lee J, Kim JH, Biter AB, Sielaff B, Lee S, Tsai FT "Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor." Proc. Natl. Acad. Sci. USA. 2013 110 : 8513-8. Pubmed PMID: 23650362
- Biter AB, Lee S, Sung N, Tsai FT "Structural basis for intersubunit signaling in a protein disaggregating machine." Proc. Natl. Acad. Sci. USA. 2012 109 : 12515-20. Pubmed PMID: 22802670
- Lee S, Sielaff B, Lee J, Tsai FT "CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation." Proc. Natl. Acad. Sci. USA. 2010 107 : 8135-40. Pubmed PMID: 20404203
- Augustin S, Gerdes F, Lee S, Tsai FT, Langer T, Tatsuta T "An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases." Mol. Cell. 2009 35 : 574-85. Pubmed PMID: 19748354
- Lee S, Choi JM, Tsai FT "Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB." Mol. Cell. 2007 25 : 261-71. Pubmed PMID: 17244533
- Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B "Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB." Cell. 2004 119 : 653-65. Pubmed PMID: 15550247
- Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT "The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state." Cell. 2003 115 : 229-40. Pubmed PMID: 14567920
- Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB, Lifton RP "Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy." Science. 2000 289 : 119-23. Pubmed PMID: 10884226
- Tsai FT, Sigler PB "Structural basis of preinitiation complex assembly on human pol II promoters." EMBO J. 2000 19 : 25-36. Pubmed PMID: 10619841
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