Email

joshua.wythe@bcm.edu

Positions

Associate Professor

Molecular Physiology and Biophysics
Baylor College of Medicine
Houston, TX US

Member

Cardiovascular Research Institute
Baylor College of Medicine
Houston, Texas United States

Addresses

Department of Molecular Physiology and Biophysics (Office)

Baylor College of Medicine
Houston, TX 77030
United States

Education

BA from Miami University

Oxford, Ohio United States

History

BS from Miami University

Oxford, Ohio United States

Botany

PhD from University of Utah School of Medicine

10/2007 - Salt Lake City, Utah United States

Oncological Sciences / Cardiovascular Development

Post-Doctoral Fellowship at University of California, San Francisco

01/2014 - San Francisco, California United States

Cardiovascular Development and Disease

Professional Interests

• Cardiovascular Development
• CNS Vascular Development and Disease
• Brain Arteriovenous Malformations
• Angiogenesis in Glioma
• Transcriptional Regulation of Organogenesis
• Mouse, Zebrafish, and Human Genetics

Selected Publications

• Fish JE, Flores Suarez CP, Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, De Ruiz KB, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD. "Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling." Circ Res. 2020 : Pubmed PMID: 32552404
• Carlson JC, Cantu-Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. "Identification of diverse tumor endothelial cell populations in malignant glioma." Neuro Oncol.. 2020 : Pubmed PMID: 33367832
• Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S,.....Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Ylä-Herttuala S, Wythe JD, Antonarakis SE, Frösen J, Fish JE, Radovanovic I. "Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain." N Engl J Med.. 2018 : Pubmed PMID: 29298116
• Wang K, Zhao S, Liu B, Zhang Q, Li Y, Liu J, Shen Y, Ding X, Lin J, Wu Y, Yan Z, Chen J, Li X, Song X, Niu Y, Liu J, Chen W, Ming Y, Du R, Chen C, Long B, Zhang Y, Tong X, Zhang S, Posey JE, Zhang B, Wu Z, Wythe JD, Liu P, Lupski JR, Yang X, Wu N. "Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM)." J Med Genet.. 2018 : Pubmed PMID: 30120215