Joshua
Middle Name
D.
Wythe, Ph.D.
Middle Name
D.
Picture

Positions
- Associate Professor
-
Molecular Physiology and Biophysics
Baylor College of Medicine
Houston, TX US
- Member
-
Cardiovascular Research Institute
Baylor College of Medicine
Houston, Texas United States
Addresses
- Department of Molecular Physiology and Biophysics (Office)
-
Baylor College of Medicine
Houston, TX 77030
United States
Education
- BA from Miami University
- Oxford, Ohio United States
- History
- BS from Miami University
- Oxford, Ohio United States
- Botany
- PhD from University of Utah School of Medicine
- 10/2007 - Salt Lake City, Utah United States
- Oncological Sciences / Cardiovascular Development
- Post-Doctoral Fellowship at University of California, San Francisco
- 01/2014 - San Francisco, California United States
- Cardiovascular Development and Disease
Professional Interests
- Cardiovascular Development
- CNS Vascular Development and Disease
- Brain Arteriovenous Malformations
- Angiogenesis in Glioma
- Transcriptional Regulation of Organogenesis
- Mouse, Zebrafish, and Human Genetics
Selected Publications
- Fish JE, Flores Suarez CP, Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, De Ruiz KB, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD. "Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling." Circ Res. 2020 Pubmed PMID: 32552404
- Carlson JC, Cantu-Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. "Identification of diverse tumor endothelial cell populations in malignant glioma." Neuro Oncol. 2020 Pubmed PMID: 33367832
- Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S,.....Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Ylä-Herttuala S, Wythe JD, Antonarakis SE, Frösen J, Fish JE, Radovanovic I. "Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain." N Engl J Med. 2018 Pubmed PMID: 29298116
- Wang K, Zhao S, Liu B, Zhang Q, Li Y, Liu J, Shen Y, Ding X, Lin J, Wu Y, Yan Z, Chen J, Li X, Song X, Niu Y, Liu J, Chen W, Ming Y, Du R, Chen C, Long B, Zhang Y, Tong X, Zhang S, Posey JE, Zhang B, Wu Z, Wythe JD, Liu P, Lupski JR, Yang X, Wu N. "Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM)." J Med Genet. 2018 Pubmed PMID: 30120215
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