Robert
Middle Name
M
Bryan Jr, Ph.D.
Middle Name
M
Picture
Robert
Middle Name
M
Bryan Jr, Ph.D.
Middle Name
M
Vice Chair for Research, Professor of Anesthesiology, Medicine, and Cellular and Molecular Physiology
Phone
Phone
Positions
- Vice Chair for Research, Professor of Anesthesiology, Medicine, and Cellular and Molecular Physiology
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Anesthesiology
Baylor College of Medicine
Houston, TX US
Education
- Postdoctoral Fellowship at Duke University
- 06/1981 - Durham, NC United States
- PhD from University Of British Columbia
- 01/1980 - Vancouver, Canada
- M.S. from University Of Alabama
- 01/1974 - Tuscaloosa, AL United States
- BS from University Of Alabama
- 05/1970 - Tuscaloosa, AL United States
Professional Statement
Our laboratory studies communications between the gut bacteria, the gut, and the brain during normal and pathological states. These studies include hypertension, stroke, aging, Alzheimer’s disease, and cerebral small vessel disease.A second line of investigation involves the control of cerebral circulation during normal and pathological states. Current projects involve the interaction between cerebrovascular endothelium and smooth muscle.
Websites
Selected Publications
- Blasco, M. P., Chauhan, A., Honarpisheh, P., Ahnstedt, H., d'Aigle, J., Ganesan, A., Ayyaswamy, S., Blixt, F., Venable, S., Major, A., Durgan, D., Haag, A., Kofler, J., Bryan, R., McCullough, L. D., Ganesh, B. P. "Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation." J. Neuroinflammation. 17 : 160.
- Spychala, M. S., Venna, V. R., Jandzinski, M., Doran, S. J., Durgan, D. J., Ganesh, B. P., Ajami, N. J., Putluri, N., Graf, J., Bryan, R. M., McCullough, L. D. "Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome." Ann.Neurol.. 2018 84 : 23-36.
- Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM, Durgan DJ "Alterations in the gut microbiota can elicit hypertension in rats." Physiol Genomics. 2017 49 : 96-104.
- Durgan,D.J.; Lee,J.; McCullough,L.D.; Bryan,R.M.,Jr. "Examining the Role of the Microbiota-Gut-Brain Axis in Stroke." Stroke. 2019 50 (8): 2270-2277. Pubmed PMID: 31272315
- Lee, J., d'Aigle, J., Atadja, L., Quaicoe, V., Honarpisheh, P., Ganesh, B. P., Hassan, A., Graf, J., Petrosino, J. F., Putluri, N., Zhu, L., Durgan, D. J., Bryan, R. M., Jr., McCullough, L. D., Venna, V. R. "Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice." Circ. Res.. 2020 127 : 435-465.
- Honarpisheh, P., Blixt, F. W., Blasco Conesa, M. P., Won, W., d'Aigle, J., Munshi, Y., Hudobenko, J., Furr, J. W., Mobley, A., Lee, J., Brannick, K. E., Zhu, L., Hazen, A. L., Bryan, R. M., McCullough, L. D., Ganesh, B. P. "Peripherally-sourced myeloid antigen presenting cells increase with advanced aging." Brain Behav.Immun.. 2020 :
- Ganesh,B.P.; Nelson,J.W.; Eskew,J.R.; Ganesan,A.; Ajami,N.J.; Petrosino,J.F.; Bryan,R.M.,Jr.; Durgan,D.J. "Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea." Hypertension. 2018 72 (5): 1141-1150. Pubmed PMID: 30354816
- Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM "Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension." Hypertension. 2016 67 (2): 469-474.
- Nelson,J.W.; Phillips,S.C.; Ganesh,B.P.; Petrosino,J.F.; Durgan,D.J.; Bryan,R.M. "The gut microbiome contributes to blood-brain barrier disruption in spontaneously hypertensive stroke prone rats." FASEB J. 2021 35 (2): e21201. Pubmed PMID: 33496989
- Lee, J., Venna, V. R., Durgan, D. J., Shi, H., Hudobenko, J., Putluri, N., Petrosino, J., McCullough, L. D., Bryan, R. M. "Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance." Gut Microbes. 2020 : 1-14.
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