Yaping Pan, Ph.D.
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Yaping Pan, Ph.D.
Assistant Professor
Positions
- Assistant Professor
-
Biochemistry-M Zhou Lab
Baylor College of Medicine
Houston, TX US
Addresses
- Baylor College of Medicine (Office)
-
BCM-Smith Medical Research Bldg
Room: BCMS-313
Houston, TX 77030
United States
(713) 798-8444
Yaping.Pan@bcm.edu
Education
- BS from Fudan University
- 06/1999 - Shanghai, China
- Pharmacology
- PhD from Peking Union Medical College
- 06/2004 - Beijing, China
- Pharmacology
- Post-Doctoral Fellowship at Baylor College of Medicine
- 09/2005 - Houston, Texas United States
- Neuroscience
- Post-Doctoral Fellowship at Columbia University
- 04/2011 - New York, New York United States
- Physiology
Honors & Awards
- First Place Award of "Outstanding Papers of Young Researchers"
- 8th Chinese Biochemical Pharmacology Academic Conference (01/2003)
Professional Statement
My research focuses on understanding function and modulation of ion channels and transporters. I obtained extensive trainings in electrophysiology and molecular biology from my Ph.D. projects and postdoctoral training. After I joined Dr. Zhou's lab, I have participated in projects of redox modulation of Kv1 channels and small-molecule modulators of Kv1 channels. I have also participated in functional characterization of several transporters, such as potassium ion transporter, urea transporter and bile acid transporter.Websites
Selected Publications
- Zhou X, Levin EJ, Pan Y, McCoy JG, Sharma R, Kloss B, Bruni R, Quick M, Zhou M. "Structural basis of the alternating-access mechanism in a bile acid transporter." Nature. 2014 January 23; 505 (7484): 569-73. Pubmed PMID: 4142352
- Cao Y*, Pan Y*, Huang H*, Jin X, Levin EJ, Kloss B, Zhou M. "Gating of the TrkH ion channel by its associated RCK protein TrkA." Nature. 2013 April 18; 496 (7445): 317-322. Pubmed PMID: 3726529
- Pan Y, Levin EJ, Quick M, Zhou M. "Potentiation of the Kv1 family K+ channel by cortisone analogues." ACS Chemical Biology. 2012 October 19; 7 (10): 1641-1646. Pubmed PMID: 3567311
- Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, Zhou M. "Structure and permeation mechanism of a mammalian urea transporter." Proceedings of the National Academy of Scienc. 2012 July 10; 109 (28): 11194-9. Pubmed PMID: 3396522
- Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson W, Javitch J, Rajashankar K, Zhou M. "Crystal structure of a phosphorylation-coupled saccharide transporter." Nature. 2011 May 5; 473 (7345): 50-54. Pubmed PMID: 3201810
- Pan Y, Weng J, Levin EJ, Zhou M. "Oxidation of NADPH inhibits ball-and-chain type inactivation by restraining the chain." Proceedings of the National Academy of Scienc. 2011 April 5; 108 (14): 5885-90. Pubmed PMID: 3078402
- Cao Y, Jin X, Huang H, Derebe M, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson W, Rost B, Javitch J, Rajashankar K, Jiang Y, Zhou M. "Crystal structure of a potassium ion transporter TrkH." Nature. 2011 March 17; 471 (7338): 336-340. Pubmed PMID: 3077569
- Rezvani K, Teng Y, Pan Y, Dani JA, Lindstrom J, García Gras EA, McIntosh JM, De Biasi M. "UBXD4, a UBX-Containing Protein, Regulates the Cell Surface Number and Stability of 3-Containing Nicotinic Acetylcholine Receptors." J. Neurosci.. 2009 May 27; 29 (21): 6883-96. Pubmed PMID: 2935801
- Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle R, Zhou M. "Cortisone dissociates Shaker family K+ channels from their Beta subunits." Nature Chemical Biology. 2008 November ; 4 (11): 708-14. Pubmed PMID: 2633621
- Pan Y, Weng J, Cao Y, Bhosle R, Zhou M. "Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1." Journal of Biological Chemistry. 2008 March 28; 283 (13): 8634-8642. Pubmed PMID: 2417172
Memberships
- Biophysical Society
- Member (01/2006)
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