Feng Yang Lab



Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann M, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F "MAPK4 Promotes Prostate Cancer by Concerted Activation of Androgen Receptor and AKT." J Clin Invest. 2021 : In press.

Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. Journal of Clinical Investigation. 2019 Mar 1;129(3):1015-29. PubMed.

Wang W, Dong B, Yang F. Avian Retrovirus-Mediated Tumor-Specific Gene Knockout. Current Protocols in Molecular Biology. 2018 Jan 16;121:23.17.1-23.17.7. PubMed

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia. 2017 May; 19(5): 421-8. PubMed

Zhong X et al. Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer. Molecular and Cellular Biology. 2016 Oct 13;36(21):2742-54. PubMed

Wang W, Dong B, Ittmann MM, Yang F. A Versatile Gene Delivery System for Efficient and Tumor Specific Gene Manipulation in vivo. Discoveries. 2016 April-June; 4(2): e58. doi: 10.15190/d.2016.5. PubMed

Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold M, Moore DD. Combined activation of CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nature Communications. 2015 Feb 9;6:5944. doi: 10.1038/ncomms6944. PubMed

Bucur O et al. An updated h-index measures both the primary and total scientific output of a researcher. Discoveries 2015 3(3): e50. PubMed

Yang F*, Chen Y, Shen T, Guo D, Dakhova O, Creighton C, Ittmann M, Dang T, Rowley DR*. Stromal TGF-β signaling induces AR activation in prostate cancer. Oncotarget. 2014 Nov 15;5(21):10854-69. PubMed

Kim W, Barron DA, Martin RS, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proceedings of the National Academy of Sciences. 2014 Nov 18;111(46):16389-94. PubMed

Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR. WFDC1 is a Key Modulator of Inflammatory and Wound Repair Responses. American Journal of Pathology. 2014 Nov;184(11):2951-64. PubMed

Strand DW, Liang YY, Yang F, Barron DA, Ressler SJ, Schauer IG, Feng XH, Rowley DR. TGF-β induction of FGF-2 expression in stromal cells requires integrated Smad3 and MAPK pathways. American Journal of Clinical and Experimental Urology. 2014 Oct 2;2:239-48. PubMed

Yang F*, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR*. FGFR1 Is Essential for Prostate Cancer Progression and Metastasis. Cancer Research. 2013 Jun 15; 73(12):3716-24. PubMed

Barron DA, Strand DW, Ressler SJ, Dang TD, Hayward SW, Yang F, Ayala GE, Ittmann M, Rowley DR. TGF-ß1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse. PLoS One. 2010 Oct 29; 5(10):e13751. PubMed

Yang F, Strand DW, Rowley DR. Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma. Oncogene. 2008 Jan 17; 27(4):450-9. PubMed

Alvarez R et al. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. Journal of Virology. 2008 Jan; 82(1):471-86. PubMed

Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD, Rowley DR. Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Research. 2005 Oct 1; 65(19):8887-95. PubMed

McAlhany SJ, Ressler SJ, Larsen M, Tuxhorn JA, Yang F, Dang TD, Rowley DR. Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. Cancer Research. 2003 Sep 15; 63(18):5859-65. PubMed

Li Y, Li H, Yang F, Smith-Gill SJ, Mariuzza RA. X-ray snapshots of the maturation of an antibody response to a protein antigen. Nature Structural Biology. 2003 Jun; 10(6):482-8. PubMed

Tuxhorn JA, McAlhany SJ, Yang F, Dang TD, Rowley DR. Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Research. 2002 Nov 1; 62(21):6021-5. PubMed

Yang F, Cheng Y, Peng J, Zhou J, Jing G. Probing the conformational state of a truncated staphylococcal nuclease R using time of flight mass spectrometry with limited proteolysis. European Journal of Biochemistry. 2001 Aug; 268(15):4227-32. PubMed

Yang F, Jing GZ, Zhou JM, Zheng YZ. Free luciferase may acquire a more favorable conformation than ribosome-associated luciferase for its activity expression. FEBS Letters. 1997 Nov; 417(3):329-32. PubMed