- Directly testing the ability of the FGFR-4 Arg388 allele to promote metastasis in vivo using transgenic and orthotopic mouse models of prostate cancer
- Determination of the mechanism by which the FGFR-4 Arg388 allele promotes increased motility and metastasis
- Confirming the role of the FGFR-4 Arg388 allele in prostate cancer incidence in a prospective trial and analysis of its impact on patient outcome in men treated with radiation therapy or watchful waiting
Wang J, Stockton D, and Ittmann M. 2004. The FGFR-4 Arg388 allele is associated with prostate cancer initiation and progression. Clin Cancer Res. 10: 6169-6178.
Ropiquet F, Giri D, Kwabi-Addo, B, Mansukhani A, and Ittmann M. 2000. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Cancer Res. 60: 4245-4250.