Mingshan Xue Lab





Chen W, Cai ZL, Chao ES, Chen H, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue M (2019) Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLife 2020;9:e48705.

Ren K, Yang H, Zhao Y, Chen W, Xue M, Miao H, Huang S, Liu J (2018) A robust AUC maximization framework with simultaneous outlier detection and feature selection for positive-unlabeled classification. IEEE Trans Neural Netw Learn Syst.

Messier J, Chen H, Cai ZL, Xue M (2018) Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon. eLife 2018;7:e38506

Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP (2018) Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome. American Journal of Human Genetics 2018 Feb 1;102(2):296-308

Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACN, Xia F, Wang MC, Maletic-Savatic M, Wang J (2017) Quantitative real-time imaging of glutathione. Nature Communications 2017;16087:10.1038/ncomms16087

Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY (2017) Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron 2017 Apr 19;94(2):294-303.e4

Messier J (2017) The role of neuroligins in the cerebellum highlights the diversity of synapse-specifying molecules. J Neurosci. 2017;37

Yin J, Chen W, Yang H, Xue M, Schaaf CP (2017) Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. Sci Rep 2017 January 3;7:39941

Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He L, Sztainberg Y, Chen W, Tang J, Zoghbi H (2016) Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. eLife 2016;5:e14198

Meng X, Wang W, Lu H, He L, Chen W, Chao E, Fiorotto M, Tang B, Herrera J, Seymour M, Neul J, Pereira F, Tang J, Xue M, Zoghbi H (2016) Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. eLife 2016;5:e14199


Before 2014 (Selected Publications):


Xue M, Atallah BV, Scanziani M (2014) Equalizing excitation-inhibition ratios across visual cortical neurons. Nature 511:596-600.

Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M (2013) Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci 16:1068-1076.

Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C (2010) Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol 17:568-575.

Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C (2009) Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron 64:367-380.

Xue M, Ma C, Craig TK, Rosenmund C, Rizo J (2008) The Janus-faced nature of the C2B domain is fundamental for Synaptotagmin-1 function. Nat Struct Mol Biol 15:1160-1168.

Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C, Reim K (2008) Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci USA 105:7875-7880.

Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund C (2007) Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol 14:949-958.

All Publications