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Chonghui Cheng Lab



A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes. Zhang J, Harvey SE, Cheng C. Nucleic Acids Res. 2019 Apr 23;47(7):3667-3679. doi: 10.1093/nar/gkz036.

CD44 splice isoform switching determines breast cancer stem cell state. Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. 2019. Genes Dev 33: 166–179. doi: 10.1101/gad.319889.118. Epub 2019 Jan 28.

DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Matsunuma R, Chan DW, Kim BJ, Singh P, Han A, Saltzman AB, Cheng C, Lei JT, Wang J, Roberto da Silva L, Sahin E, Leng M, Fan C, Perou CM, Malovannaya A, Ellis MJ. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11978-E11987. doi: 10.1073/pnas.1810598115. Epub 2018 Nov 29. PMID: 30498031

Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD. BMC Biol. 2018 Jun 21;16(1):69. doi: 10.1186/s12915-018-0529-0. PMID: 29925370

Co-regulation of alternative splicing by hnRNPM and ESRP1 during EMT. Harvey, SE, Xu Y, Lin X, Gao XD, Qiu Y, Ahn J, Xiao X, Cheng C. RNA. 2018 Oct;24(10):1326-1338. doi: 10.1261/rna.066712.118. Epub 2018 Jul 24.

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF. Huang H, Zhang J, Harvey SE, Hu X, Cheng C. Genes Dev. 2017 Nov 15;31(22):2296-2309. doi: 10.1101/gad.305862.117. Epub 2017 Dec 21.

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A. Wang W, Zhang H, Liu S, Kim CK, Xu Y, Hurley LA, Nishikawa R, Nagane M, Hu B, Stegh AH, Cheng SY, Cheng C. Proceedings of the National Academy of Sciences of the United States of America. 2017. Aug 1;114(31):8366-8371

Akt signaling is sustained by a CD44 splice isoform-mediated positive feedback loop. Liu S, Cheng C. Cancer Res. 2017 Jul 15;77(14):3791-3801. doi: 10.1158/0008-5472.CAN-16-2545. Epub 2017 May 22.

The CD44s splice isoform is a central mediator for invadopodia activity. Zhao Pu, Xu Yilin, Wei Yong, Qiu Qiong, Chew Teng Leong, Kang Yibin, Cheng Chonghui. Journal of Cell Science. 2016 Apr;129(7):11.

Methods for characterization of alternative RNA splicing. Harvey Samuel E., Cheng Chonghui. Methods in Molecular Biology. 2016 Jan;13.

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood. Halo Tiffany L., McMahon Kaylin M., Angeloni Nicholas L., Xu Yilin, Wang Wei, Chinen Alyssa B., Malin Dmitry, Strekalova Elena, Cryns Vincent L., Cheng Chonghui, Mirkin Chad A., Thaxton C. Shad. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec 2;111(48):6.

Detection of alternative splicing during epithelial-mesenchymal transition. Huang Huilin, Xu Yilin, Cheng Chonghui. Journal of Visualized Experiments. 2014 Oct 9;(92).

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Xu Yilin, Gao Xin D., Lee Jae Hyung, Huang Huilin, Tan Haiyan, Ahn Jaegyoon, Reinke Lauren M., Peter Marcus E., Feng Yue, Gius David, Siziopikou Kalliopi P., Peng Junmin, Xiao Xinshu, Cheng Chonghui. Genes and Development. 2014 Jun;28(11):13.

Alternative RNA splicing and cancer. Liu Sali, Cheng Chonghui. Wiley Interdisciplinary Reviews: RNA. 2013 Sep;4(5):20.

CD44 promotes Kras-dependent lung adenocarcinoma. Zhao P., Damerow M. S., Stern P., Liu A. H., Sweet-Cordero A., Siziopikou K., Neilson J. R., Sharp P. A., Cheng C. Oncogene. 2013 Jan;32(43):5.

Snail represses the splicing regulator epithelial splicing regulatory protein 1 to promote epithelial-mesenchymal transition. Reinke Lauren M., Xu Yilin, Cheng Chonghui. Journal of Biological Chemistry. 2012 Oct 19;287(43):8.

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. Brown Rhonda L., Reinke Lauren M., Damerow Marin S., Perez Denise, Chodosh Lewis A., Yang Jing, Cheng Chonghui. Journal of Clinical Investigation. 2011 Mar;121(3):11.