Functional and Cognitive Neurophysiology Laboratory

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About the Lab

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The Functional and Cognitive Neurophysiology laboratory, led by Dr. Sameer Sheth, focuses on the study of human decision-making and cognition, as well as on the development of novel therapies for neuropsychiatric disorders. To accomplish these goals, we take a two-fold approach.

First, we work with neurosurgical patients undergoing deep brain stimulation (DBS), epilepsy monitoring, and other procedures that require the placement of intracranial electrodes. We use single-neuron and field potential recordings as well as stimulation to understand the circuitry underlying complex cognitive functions such as controlled decision-making, memory formation, and emotional regulation.

Second, we develop and refine neuromodulatory treatments for refractory neurological and psychiatric disorders such as obsessive-compulsive disorder (OCD), depression, and many others. These disorders often arise from dysfunction in the same circuits mentioned above.

Thus the two efforts advance synergistically, with a constant back-and-forth flow of ideas. Because of the multi-disciplinary nature of this work, the lab interacts closely with many other disciplines, including Neuroscience, Psychiatry, Neurology, Computational Science, Engineering, and others.

See a list of publications
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Research Projects

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  • Individualized Intracranial Recording and Stimulation
  • Investigating the Neural Mechanisms Underlying Ad-Hoc Self-Programmability
  • Investigating the Physiology of Controlled Decision-Making in Human Prefrontal Cortex 
  • Investigating Cortical and Basal Ganglia Networks Involved in Disorders of Mental Health 
  • Developing Novel Targets and Indications for Neuromodulation
Review our current Research Projects
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Ask Me About My Research

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Sameer Sheth, M.D., Ph.D., associate professor and vice-chair of clinical research in the department neurosurgery is joined by a special guest to demonstrate the importance of scientists and researchers talking with others about their work.