Elucidating the Molecular Evolution of Triple Negative Breast Cancer
About the Lab
Our goal: Tackling the molecular evolution of triple negative breast cancer therapy resistance and metastasis
Cancers are ecosystems of diverse tumor and stroma cell subpopulations each capable of having a variety of roles in tumor progression. While the existence of this complex intra-tumor heterogeneity has been thoroughly documented, its functional repercussions are not well understood. We investigate the genomic and metabolic evolution of triple negative breast cancers (TNBCs) as they resist therapies and metastasize to secondary organs. We leverage state-of-the-art technologies in clinically relevant experimental models of TNBC to discover impactful mechanisms. Our ultimate goal is to improve clinical outcomes of women living with TNBC.