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Yongcheng Song Lab

Publications

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Selected Publications

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Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y. "Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.." J. Am. Chem. Soc.. 2011 October 26;133(42):16746-9. Pubmed PMID: 21936531

Anglin, J. L. Song, Y.. "A Medicinal Chemistry Perspective for Targeting Histone H3K79 Methyltransferase DOT1L." J. Med. Chem.. 2013;56:8972-8983. Pubmed PMID: 23879463

Zheng, B. Yao, Y. Liu, Z. Deng, L. Anglin, J. L. Jiang, H. Prasad, B. V. V. Song, Y.. "Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase." ACS Med. Chem. Lett.. 2013;4:542-546. Pubmed PMID: 23795241

Xue, J. Diao, J. Cai, G. Deng, L. Zheng, B. Yao, Y. Song, Y.. "Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase." ACS Med. Chem. Lett.. 2013;4:278–282. Pubmed PMID: 23795240

Zhang, L. Deng, L. Chen, F. Yao, Y. Wu, B. Wei, L. Mo, Q. Song, Y.. "Inhibition of Histone H3K79 Methylation Selectively Inhibits Proliferation, Self-renewal and Metastatic Potential of Breast Cancer." Oncotarget. 2014;5:10665-77. Pubmed PMID: 25359765

Liu, Z. Yao, Y. Kogiso, M. Zheng, B. Deng, L. Qiu, J. J. Dong, S. Lv, H. Gallo, J. M. Li, X.-N. Song, Y.. "Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, SAR and Selective Antitumor Activity." J. Med. Chem.. 2014;57:8307-18. Pubmed PMID: 25271760

Wu, F. Zhou, C. Yao, Y. Wei, L. Feng, Z. Deng, L. Song, Y.. "3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.." J. Med. Chem.. 2016;59:253. Pubmed PMID: 26652247

Wu, F. Zheng, B. Jiang, H. Kogiso, M. Yao, Y. Zhou, C. Song, Y.. "Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.." J. Med. Chem.. 2015;58:6899. Pubmed PMID: 26280302

Feng, Z. Zhou, C. Wu, F. Yao, Y. Wei, L. Liu, W. Dong, S. Redell, M. Song, Y.. "Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.." J. Hematol. Oncol.. 2016;9:24. Pubmed PMID: 26970896

Lu, L. Wen, Y. Yao, Y. Chen, F. Wang, G. Wu, F. Wu, J. Narayanan, P. Redell, M. Mo, Q. Song, Y.. "Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation (8;21).." Theranostics. 2018;8:2189.